Peptide nucleic acids (PNAs) are an important class of DNA/RNA mimics that can hybridize
complementary chains of nucleic acids with high affinity and specificity. Because of this …

Background Researchers now have a new avenue to investigate when it comes to miRNA-
based therapeutics. miRNAs have the potential to be valuable biomarkers for disease …

Clinical advances enable the prenatal diagnosis of genetic diseases that are candidates for
gene and enzyme therapies such as messenger RNA (mRNA)–mediated protein …

Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …

RNA interference (RNAi) is a major cellular mechanism regulating gene expression in which
short double-stranded RNA molecules called small interfering RNA (siRNA) mediate …

Nucleic acid-based therapy emerges as a powerful weapon for the treatment of tumors
thanks to its direct, effective, and lasting therapeutic effect. Encouragingly, continuous …

The self-assembly of inorganic nanoparticles to larger structures is of great research interest
as it allows the fabrication of novel materials with collective properties correlated to the …

Cancerous tumours contain a rare subset of cells with stem‐like properties that are termed
cancer stem cells (CSCs). CSCs are defined by their ability to divide both symmetrically and …

Gene delivery systems necessitate the gene therapy, which is a unique approach for
applying the tunable genes to treat any diseases. To tackle down the disadvantages of viral …

Antisense peptide nucleic acids (PNAs) have yet to translate to the clinic because of poor
cellular uptake, limited solubility, and rapid elimination. Cell-penetrating peptides (CPPs) …