Dermal fibroblasts, which make up the major cell type in the dermis, have, historically, been
considered to be relatively 'passive'cells which are responsible for the synthesis and …

Wound repair is a complex biologic process which becomes abnormal in numerous disease
states. Although in vitro models have been important in identifying critical repair pathways in …

The most common form of heart failure occurs with normal systolic function and often
involves cardiac hypertrophy in the elderly. To clarify the biological mechanisms that drive …

Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate
all mature blood cells. HSC function is tightly controlled to maintain haematopoietic …

Stem cells are fundamental units for achieving regenerative therapies, which leads naturally
to a theoretical and experimental focus on these cells for therapeutic screening and …

Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450
(CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases …

Diabetic ulcers represent a substantial societal and healthcare burden worldwide and
scarcely respond to current treatment strategies. This study was addressed to evaluate the …

Integrative organ crosstalk regulates key aspects of energy homeostasis, and its
dysregulation may underlie metabolic disorders such as obesity and diabetes. To test the …

Type II diabetes mellitus (T2DM) is one of the most prevalent diseases in the world,
associated with diabetic foot ulcers and impaired wound healing. There is an ongoing need …

Diabetes mellitus (DM) is a metabolic disease frequently associated with impaired bone
healing. Despite its increasing prevalence worldwide, the molecular etiology of DM-linked …