Oxidative stress and hyper-inflammation as major drivers of severe COVID-19 and long COVID: implications for the benefit of high-dose intravenous vitamin C

C Vollbracht, K Kraft - Frontiers in Pharmacology, 2022 - frontiersin.org
Oxidative stress is a pivotal point in the pathophysiology of COVID-19 and presumably also
in Long-COVID. Inflammation and oxidative stress are mutually reinforcing each other, thus …

Vitamin C and COVID-19 treatment: A systematic review and meta-analysis of randomized controlled trials

D Rawat, A Roy, S Maitra, A Gulati, P Khanna… - Diabetes & Metabolic …, 2021 - Elsevier
Background and aims Vitamin C has been used as an anti-oxidant in various diseases
including viral illnesses like coronavirus disease (COVID-19). Methods Meta-analysis of …

Vitamin C in the Treatment of COVID-19

GP Milani, M Macchi, A Guz-Mark - Nutrients, 2021 - mdpi.com
Vitamin C is an essential nutrient that serves as antioxidant and plays a major role as co-
factor and modulator of various pathways of the immune system. Its therapeutic effect during …

Nutritional risk of vitamin D, vitamin C, zinc, and selenium deficiency on risk and clinical outcomes of COVID-19: A narrative review

LFC Pedrosa, ANAB Barros, L Leite-Lais - Clinical nutrition ESPEN, 2022 - Elsevier
The pathogenicity of the current coronavirus disease (COVID-19) shows postulates that
optimal status of essential nutrients is crucial in supporting both the early viraemic and later …

Vitamin C supplementation for the treatment of COVID-19: a systematic review and meta-analysis

M Olczak-Pruc, D Swieczkowski, JR Ladny, M Pruc… - Nutrients, 2022 - mdpi.com
Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, caused by the
severe respiratory syndrome coronavirus 2 (SARS-CoV-2), millions of people have died …

Does evidence exist to blunt inflammatory response by nutraceutical supplementation during covid-19 pandemic? An overview of systematic reviews of vitamin d …

S Corrao, R Mallaci Bocchio, M Lo Monaco, G Natoli… - Nutrients, 2021 - mdpi.com
More than one year has passed since the first cases of coronavirus disease 2019 (COVID-
19) caused by severe acute respiratory syndrome (SARS)-CoV-2 coronavirus were reported …

[HTML][HTML] Clinical significance of micronutrient supplements in patients with coronavirus disease 2019: A comprehensive systematic review and meta-analysis

A Beran, M Mhanna, O Srour, H Ayesh, JM Stewart… - Clinical nutrition …, 2022 - Elsevier
Background and aims Micronutrient supplements such as vitamin D, vitamin C, and zinc
have been used in managing viral illnesses. However, the clinical significance of these …

Parenteral vitamin C in patients with severe infection: a systematic review

A Agarwal, J Basmaji, SM Fernando, FZ Ge… - NEJM …, 2022 - evidence.nejm.org
Background Inflammation and oxidative damage caused by severe infections may be
attenuated by vitamin C. Methods We conducted a systematic review of randomized …

[HTML][HTML] The coronavirus disease (COVID-19)–A supportive approach with selected micronutrients

U Gröber, MF Holick - International Journal for Vitamin and …, 2021 - econtent.hogrefe.com
Worldwide the pandemic of COVID-19 spreads rapidly and has had an enormous public
health impact with substantial morbidity and mortality especially in high-risk groups, such as …

The effects of vitamin C on respiratory, allergic and immunological diseases: an experimental and clinical-based review

MHE Ghalibaf, F Kianian, S Beigoli, S Behrouz… - …, 2023 - Springer
Vitamin C is used in modern medicine supplements for treatment of various disorders
associated with oxidative stress, inflammation and immune dysregulation. In this review …