Cell metabolism is the biochemical machinery that provides energy and building blocks to
sustain life. Understanding its fine regulation is of pivotal relevance in several fields, from …

Multiple input changes can cause unwanted switching variations, or glitches, in the output of
genetic combinational circuits. These glitches can have drastic effects if the output of the …

(Special section 'Design, modelling and control of electric vehicles') This study provides a
detailed deterministic and stochastic sensitivity analysis of the propulsion energy cost of …

This study concerns the analysis of the modulation of Chronic Myeloid Leukemia (CML) cell
model K562 transcriptome following transfection with the tumor suppressor gene encoding …

Identifying the key factors underlying the spread of a disease is an essential but challenging
prerequisite to design management strategies. To tackle this issue, we propose an approach …

A simple, two-layer energy balance model (EBM) is used to investigate climate variability in
Coupled Model Intercomparison Project Phase 5 (CMIP5) models and examine possible …

Background Genome-wide reconstructions of metabolism opened the way to thorough
investigations of cell metabolism for health care and industrial purposes. However, the …

Abstract Background The parasite Leishmania infantum causes zoonotic visceral
leishmaniasis (VL), a potentially fatal vector-borne disease of canids and humans. Zoonotic …

Severe accident mitigation strategies in Nordic boiling water reactors (BWRs) employ core
melt cooling in a deep pool of water under the reactor pressure vessel. Corium melt …

To study the effects of a delayed immune-response on the growth of an immunogenic
neoplasm we introduce Stochastic Hybrid Automata with delayed transitions as a …