Immunoinformatics-guided approach for designing a pan-proteome multi-epitope subunit vaccine against African swine fever virus

AM Simbulan, EC Banico, EMJS Sira… - Scientific Reports, 2024 - nature.com
Despite being identified over a hundred years ago, there is still no commercially available
vaccine for the highly contagious and deadly African swine fever virus (ASFV). This study …

[HTML][HTML] Advancement in the development of gene/protein-based vaccines against African swine fever virus

N Wang, P Huang, J Zhang, M Lin, X Lai, J Chen… - Current Research in …, 2024 - Elsevier
African swine fever (ASF) is a highly contagious acute hemorrhagic viral disease, with the
mortality rate of up to 100% in domestic pigs. In recent years, ASF outbreaks have caused …

Immunization of pigs with replication-incompetent adenovirus-vectored African swine fever virus multi-antigens induced humoral immune responses but no protection …

MD Zajac, JD Trujillo, J Yao, R Kumar… - Frontiers in Veterinary …, 2023 - frontiersin.org
Introduction African swine fever virus (ASFV) is a pathogen of great economic importance
given that continues to threaten the pork industry worldwide, but there is no safe vaccine or …

Defining correlates of protection for mammalian livestock vaccines against high-priority viral diseases

SK Davis, F Jia, QG Wright, MT Islam, A Bean… - Frontiers in …, 2024 - frontiersin.org
Enhancing livestock biosecurity is critical to safeguard the livelihoods of farmers, global and
local economies, and food security. Vaccination is fundamental to the control and prevention …

Identification of the p34 protein of African swine fever virus as a novel viral antigen with protection potential

X Zhang, X Guan, Q Wang, X Wang, X Yang, S Li… - Viruses, 2023 - mdpi.com
African swine fever (ASF) is a highly contagious disease caused by African swine fever virus
(ASFV), affecting domestic and wild boars. The polyprotein pp220 of ASFV is responsible for …

A porcine kidney-derived clonal cell line with clear genetic annotation is highly susceptible to African swine fever virus

H Cao, M Zhang, Z Liao, D Li, X He, H Ma, P Li, X Yu… - Veterinary …, 2024 - Springer
Abstract African Swine Fever virus (ASFV), the causative agent of African swine fever, is a
highly lethal hemorrhagic virus affecting domestic pigs and wild boars. The primary target …

Ferritin nanoparticles significantly enhance the immune response to the African swine fever virus p34 protein

R Zhang, Y Ru, R Hao, Y Yang, L Zhao, Y Zhang… - International Journal of …, 2025 - Elsevier
Background African swine fever (ASF) is a highly contagious disease, and the core–shell
protein p34 is an important antigen that can induce immune responses. The use of ferritin …

[HTML][HTML] Newcastle Disease Virus-Vectored African Swine Fever Virus Antigen Cocktail Delays the Onset of ASFV-SY18 but Is Not Protective

Q Li, Y Jiang, M Zheng, X Sun, L Hui, Y Zhang, H Yue… - Microorganisms, 2024 - mdpi.com
African Swine Fever (ASF) is a highly contagious viral disease threatening the global pig
industry. Currently, only two gene-deleted live attenuated vaccines are approved …

Development and characterization of monoclonal antibodies against p37 protein of African swine fever virus

A Wang, Z Chen, J Zhou, Y Chen, Y Liu, H Liu… - International Journal of …, 2024 - Elsevier
Abstract African Swine Fever Virus (ASFV) is a highly contagious pathogen posing a serious
threat to the global swine industry. Despite this, there is currently no effective vaccine …

ASFV Subunit Vaccines: Strategies and Prospects for Future Development

Y Zhang, X Mei, C Zhang, H Wang, X Xie, Z Zhang… - Microbial …, 2024 - Elsevier
Abstract African Swine Fever (ASF) is an acute, highly contagious, and lethal disease
caused by the African Swine Fever Virus (ASFV), posing a severe threat to the global pig …