Liver fibrosis: mechanistic concepts and therapeutic perspectives

N Roehlen, E Crouchet, TF Baumert - Cells, 2020 - mdpi.com
Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective

MH Farzaei, M Zobeiri, F Parvizi, FF El-Senduny… - Nutrients, 2018 - mdpi.com
Oxidative stress has been considered a key causing factor of liver damage induced by a
variety of agents, including alcohol, drugs, viral infections, environmental pollutants and …

Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury

M Ashrafizadeh, Z Ahmadi… - Current Molecular …, 2020 - ingentaconnect.com
Curcumin is a naturally occurring polyphenol that is isolated from the rhizome of Curcuma
longa (turmeric). This medicinal compound has different biological activities, including …

[HTML][HTML] Nuclear factor erythroid 2-related factor 2-mediated signaling and metabolic associated fatty liver disease

VN Bukke, A Moola, G Serviddio… - World journal of …, 2022 - ncbi.nlm.nih.gov
Oxidative stress is a key driver in the development and progression of several diseases,
including metabolic associated fatty liver disease (MAFLD). This condition includes a wide …

[HTML][HTML] Antioxidants in liver health

S Casas-Grajales, P Muriel - World journal of gastrointestinal …, 2015 - ncbi.nlm.nih.gov
Liver diseases are a worldwide medical problem because the liver is the principal
detoxifying organ and maintains metabolic homeostasis. The liver metabolizes various …

Oxidative stress and Parkinson's disease: conflict of oxidant-antioxidant systems

M Hemmati-Dinarvand, M Valilo… - Neuroscience …, 2019 - Elsevier
Parkinson's disease (PD) is defined as a chronic neurodegenerative disorder which is
diagnosed mostly by its clinical manifestations. Reactive oxygen species (ROS) are …

Naturally occurring Nrf2 activators: potential in treatment of liver injury

RN Jadeja, KK Upadhyay, RV Devkar… - … Medicine and Cellular …, 2016 - Wiley Online Library
Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative
stress frequently triggers antioxidant response by activating nuclear erythroid 2‐related …

The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver …

S Saadati, B Hatami, Z Yari, MA Shahrbaf… - European journal of …, 2019 - nature.com
Background Nonalcoholic fatty liver disease (NAFLD) is a major global health problem. The
most common cause of death in these patients is due to cardiovascular disorders. The aim of …

Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-κB translocation

R Afrin, S Arumugam, A Rahman, MII Wahed… - International …, 2017 - Elsevier
Curcumin, a phenolic compound, has a wide spectrum of therapeutic effects such as
antitumor, anti-inflammatory, anti-cancer and so on. The study aimed to investigate the …

Molecular mechanisms of curcumin in the pathogenesis of metabolic dysfunction associated Steatotic liver disease

M Guariglia, F Saba, C Rosso, E Bugianesi - Nutrients, 2023 - mdpi.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial
condition characterized by insulin resistance, oxidative stress, chronic low-grade …