Masquerading microbial pathogens: capsular polysaccharides mimic host-tissue molecules

BF Cress, JA Englaender, W He… - FEMS microbiology …, 2014 - academic.oup.com
The increasing prevalence of antibiotic-resistant bacteria portends an impending
postantibiotic age, characterized by diminishing efficacy of common antibiotics and routine …

Microbial hyaluronic acid production

BF Chong, LM Blank, R Mclaughlin… - Applied microbiology and …, 2005 - Springer
Abstracts Hyaluronic acid (HA) is a commercially valuable medical biopolymer increasingly
produced through microbial fermentation. Viscosity limits product yield and the focus of …

Current advances in the biosynthesis of hyaluronic acid with variable molecular weights

Y Qiu, Y Ma, Y Huang, S Li, H Xu, E Su - Carbohydrate Polymers, 2021 - Elsevier
Hyaluronic acid (HA) is a naturally formed acidic mucopolysaccharide, with excellent
moisturising properties and used widely in the medicine, cosmetics, and food industries. The …

Hyaluronic Acid Production in Bacillus subtilis

B Widner, R Behr, S Von Dollen, M Tang… - Applied and …, 2005 - Am Soc Microbiol
The hasA gene from Streptococcus equisimilis, which encodes the enzyme hyaluronan
synthase, has been expressed in Bacillus subtilis, resulting in the production of hyaluronic …

Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms

JD de Oliveira, LS Carvalho, AMV Gomes… - Microbial cell …, 2016 - Springer
Hyaluronic acid, or HA, is a rigid and linear biopolymer belonging to the class of the
glycosaminoglycans, and composed of repeating units of the monosaccharides glucuronic …

[HTML][HTML] Invited review: a critical appraisal of mastitis vaccines for dairy cows

P Rainard, FB Gilbert, P Germon, G Foucras - Journal of Dairy Science, 2021 - Elsevier
Infections of the mammary gland remain a frequent disease of dairy ruminants that
negatively affect animal welfare, milk quality, farmer serenity, and farming profitability and …

Hyaluronan synthase: the mechanism of initiation at the reducing end and a pendulum model for polysaccharide translocation to the cell exterior

PH Weigel - International Journal of Cell Biology, 2015 - Wiley Online Library
Hyaluronan (HA) biosynthesis has been studied for over six decades, but our understanding
of the biochemical details of how HA synthase (HAS) assembles HA is still incomplete. Class …

Glycosaminoglycan polysaccharide biosynthesis and production: today and tomorrow

PL DeAngelis - Applied Microbiology and Biotechnology, 2012 - Springer
Glycosaminoglycans [GAGs] are essential heteropolysaccharides in vertebrate tissues that
are also, in certain cases, employed as virulence factors by microbes. Hyaluronan [HA] …

Metabolic engineering of Bacillus subtilis for the efficient biosynthesis of uniform hyaluronic acid with controlled molecular weights

Y Jia, J Zhu, X Chen, D Tang, D Su, W Yao… - Bioresource technology, 2013 - Elsevier
Bacillus subtilis was engineered into an efficient hyaluronic acid (HA) producer by
introducing two inducible artificial operons carrying HA synthase gene from Pasteurella …

Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis

PN Ward, MTG Holden, JA Leigh, N Lennard, A Bignell… - BMC genomics, 2009 - Springer
Abstract Background Streptococcus uberis, a Gram positive bacterial pathogen responsible
for a significant proportion of bovine mastitis in commercial dairy herds, colonises multiple …