Control of DNA replication timing in the 3D genome
The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
DNA replication origin activation in space and time
M Fragkos, O Ganier, P Coulombe… - Nature reviews Molecular …, 2015 - nature.com
DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …
Mouse heterochromatin adopts digital compaction states without showing hallmarks of HP1-driven liquid-liquid phase separation
The formation of silenced and condensed heterochromatin foci involves enrichment of
heterochromatin protein 1 (HP1). HP1 can bridge chromatin segments and form liquid …
heterochromatin protein 1 (HP1). HP1 can bridge chromatin segments and form liquid …
DNA replication timing
N Rhind, DM Gilbert - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin
structure, and genome evolution. Recent advances in genome-scale mapping of replication …
structure, and genome evolution. Recent advances in genome-scale mapping of replication …
Chromatin replication and epigenome maintenance
Stability and function of eukaryotic genomes are closely linked to chromatin structure and
organization. During cell division the entire genome must be accurately replicated and the …
organization. During cell division the entire genome must be accurately replicated and the …
DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity
DNA replication timing and three-dimensional (3D) genome organization are associated
with distinct epigenome patterns across large domains. However, whether alterations in the …
with distinct epigenome patterns across large domains. However, whether alterations in the …
Heterochromatin organization and phase separation
H Zhang, W Qin, H Romero, H Leonhardt, MC Cardoso - Nucleus, 2023 - Taylor & Francis
The eukaryotic nucleus displays a variety of membraneless compartments with distinct
biomolecular composition and specific cellular activities. Emerging evidence indicates that …
biomolecular composition and specific cellular activities. Emerging evidence indicates that …
Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following γ-irradiation
LC Young, DW McDonald, MJ Hendzel - Journal of Biological Chemistry, 2013 - ASBMB
DNA damage evokes a complex and highly coordinated DNA damage response (DDR) that
is integral to the suppression of genomic instability. Double-strand breaks (DSBs) are …
is integral to the suppression of genomic instability. Double-strand breaks (DSBs) are …
Evidence for low nanocompaction of heterochromatin in living embryonic stem cells
C Dupont, D Chahar, A Trullo, T Gostan… - The EMBO …, 2023 - embopress.org
Despite advances in the identification of chromatin regulators and genome interactions, the
principles of higher‐order chromatin structure have remained elusive. Here, we applied …
principles of higher‐order chromatin structure have remained elusive. Here, we applied …
Epigenetic regulation of nuclear processes in fungal plant pathogens
Through the association of protein complexes to DNA, the eukaryotic nuclear genome is
broadly organized into open euchromatin that is accessible for enzymes acting on DNA and …
broadly organized into open euchromatin that is accessible for enzymes acting on DNA and …