Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling

L Zhao, HL Ciallella, LM Aleksunes, H Zhu - Drug discovery today, 2020 - Elsevier
Highlights•Drug discovery has been advanced to a big data era with a large amount of
public data sources available.•Ten V features (volume, velocity, variety, veracity, validity …

Advances in smoking related in vitro inhalation toxicology: A perspective case of challenges and opportunities from progresses in lung-on-chip technologies

AV Singh, RS Maharjan, C Kromer, P Laux… - Chemical Research …, 2021 - ACS Publications
The inhalation toxicology of multifaceted particulate matter from the environment, cigarette
smoke, and e-cigarette liquid vapes is a major research topic concerning the adverse effect …

Reversed-engineered human alveolar lung-on-a-chip model

D Huang, T Liu, J Liao, S Maharjan… - Proceedings of the …, 2021 - National Acad Sciences
Here, we present a physiologically relevant model of the human pulmonary alveoli. This
alveolar lung-on-a-chip platform is composed of a three-dimensional porous hydrogel made …

A biomimetic human Lung‐on‐a‐Chip with colorful display of microphysiological breath

Y Zhu, L Sun, Y Wang, L Cai, Z Zhang… - Advanced …, 2022 - Wiley Online Library
Lung‐on‐a‐chip models hold great promise for disease modeling and drug screening.
Herein, inspired by the iridescence phenomenon of soap bubbles, a novel biomimetic 3D …

[HTML][HTML] Advances of microfluidic lung chips for assessing atmospheric pollutants exposure

H Wang, F Yin, Z Li, W Su, D Li - Environment International, 2023 - Elsevier
Atmospheric pollutants, including particulate matters, nanoparticles, bioaerosols, and some
chemicals, have posed serious threats to the environment and the human's health. The …

Alveolar wars: the rise of in vitro models to understand human lung alveolar maintenance, regeneration, and disease

KV Evans, JH Lee - Stem Cells Translational Medicine, 2020 - academic.oup.com
Diseases such as idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and
bronchopulmonary dysplasia injure the gas-exchanging alveoli of the human lung. Animal …

Airway-on-a-chip: designs and applications for lung repair and disease

TJ Bennet, A Randhawa, J Hua, KC Cheung - Cells, 2021 - mdpi.com
The lungs are affected by illnesses including asthma, chronic obstructive pulmonary
disease, and infections such as influenza and SARS-CoV-2. Physiologically relevant models …

Innovative three-dimensional models for understanding mechanisms underlying lung diseases: powerful tools for translational research

M Nizamoglu, MM Joglekar, CR Almeida… - European …, 2023 - Eur Respiratory Soc
Chronic lung diseases result from alteration and/or destruction of lung tissue, inevitably
causing decreased breathing capacity and quality of life for patients. While animal models …

Modeling mucus physiology and pathophysiology in human organs-on-chips

Z Izadifar, A Sontheimer-Phelps, BA Lubamba… - Advanced Drug Delivery …, 2022 - Elsevier
The surfaces of human internal organs are lined by a mucus layer that ensures symbiotic
relationships with commensal microbiome while protecting against potentially injurious …

[HTML][HTML] On the path to predicting immune responses in the lung: modeling the pulmonary innate immune system at the air-liquid interface (ALI)

J Graf, M Trautmann-Rodriguez, S Sabnis… - European Journal of …, 2023 - Elsevier
Chronic respiratory diseases and infections are among the largest contributors to death
globally, many of which still have no cure, including chronic obstructive pulmonary disorder …