Mast cells are tissue-resident cells, which have been proposed to participate in various
inflammatory diseases, among them the cardiovascular diseases (CVDs). For mast cells to …

On the basis of the principle of combination of active structural moieties, a modified and
efficient synthetic method for three series of novel indole-based 1, 3, 4-oxadiazoles is …

Leukocytes and lung structural cells contribute to the pathophysiology of asthma through the
production of numerous mediators including serine proteases. Such proteases include mast …

Pdâ•’Catalyzed Crossâ•’Coupling Reactions with Carbonyls: Application in a Very Efficient
Synthes Page 1 2008 Pyridine derivatives R 0380 Pd-Catalyzed Cross-Coupling Reactions …

Transition-metal ion catalyzed intramolecular dual C–H activation to construct polycyclic
heteroarene skeletons is merited for its step and atom-economic advantages in organic …

Privileged structures have been used in drug discovery targeting G protein-coupled
receptors (GPCR) and other protein classes for more than 20 years. Their rich activity …

Over 200 synthetic cannabinoid receptor agonists (SCRAs) have been identified as new
psychoactive substances. Effective monitoring and characterization of SCRAs are hindered …

Trifluoromethyl ketones are important enzyme inhibitors and versatile synthons for the
preparation of trifluoromethylated heterocycles and complex molecules. An efficient …

A variety of N-alkylated and N-arylated derivatives of methyl 1 H-indole-3-carboxylate were
synthesized efficiently via Ullmann-type intramolecular arylamination, using the CuI …

ADB-HEXINACA has been recently reported as a synthetic cannabinoid receptor agonist
(SCRA), one of the largest classes of new psychoactive substances (NPSs). This compound …