The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP)
show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 …

Endotoxemia is closely related to many diseases. As the largest endotoxin reservoir in the
human body, the gut microbiota should be a key target for alleviating endotoxemia. The …

MARCKS (myristoylated alanine-rich C-kinase substrate) is a membrane-associated protein
expressed in many cell types, including macrophages. MARCKS is functionally implicated in …

In the domain of computer-aided drug design, achieving precise and accurate estimates of
ligand–protein binding is paramount in the context of screening extensive drug libraries and …

Gut microbiota dysbiosis could aggravate the development of ulcerative colitis (UC).
Companilactobacillus crustorum MN047 (CCMN) is a potential gut microbiota-regulating …

Companilactobacillus crustorum MN047-derived bacteriocins (CCDB) have inhibitory effects
on the growth of pathogens. In this study, a pectin/zein beads delivery system was used to …

Immune sensing of the Gram-negative bacterial membrane glycolipid lipopolysaccharide
(LPS) is both a critical component of host defense against bacterial infection and a …

Purpose To investigate the antifungal and anti-inflammatory effects of quercetin in
Aspergillus fumigatus (A. fumigatus) keratitis. Methods Draize eye test was performed in …

Site Identification by Ligand Competitive Saturation (SILCS) is a molecular simulation
approach that uses diverse small solutes in aqueous solution to obtain functional group …

Context Imbalance of the skin microbial community could impair skin immune homeostasis
and thus trigger skin lesions. Dysbiosis of skin microbiome may be involved in the early …