Epigenetic mechanisms of rapid-acting antidepressants

A Inserra, A Campanale, T Rezai, P Romualdi… - Translational …, 2024 - nature.com
Abstract Background Rapid-acting antidepressants (RAADs), including dissociative
anesthetics, psychedelics, and empathogens, elicit rapid and sustained therapeutic …

Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies

G Costa, MA De Luca, G Piras, J Marongiu… - Neural regeneration …, 2020 - journals.lww.com
Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to
having abuse potential, may elicit toxic effects of varying severity at the peripheral and …

Cardiac effects of ephedrine, norephedrine, mescaline, and 3, 4-methylenedioxymethamphetamine (MDMA) in mouse and human atrial preparations

J Neumann, K Azatsian, C Höhm, B Hofmann… - Naunyn-Schmiedeberg's …, 2023 - Springer
The use of recreational drugs like ephedrine, norephedrine, 3, 4-
methylenedioxymethamphetamine (MDMA), and mescaline can lead to intoxication and, at …

Long-term effects of very low dose particle radiation on gene expression in the heart: degenerative disease risks

VNS Garikipati, A Arakelyan, EA Blakely, PY Chang… - Cells, 2021 - mdpi.com
Compared to low doses of gamma irradiation (γ-IR), high-charge-and-energy (HZE) particle
IR may have different biological response thresholds in cardiac tissue at lower doses, and …

Effects of continuous bisphenol A exposure from early gestation on 90 day old rat testes function and sperm molecular profiles: a CLARITY-BPA consortium study

E Dere, LM Anderson, SM Huse, DJ Spade… - Toxicology and applied …, 2018 - Elsevier
Bisphenol A (BPA) is a ubiquitous industrial chemical that has been identified as an
endocrine disrupting compound (EDC). There is growing concern that early life exposures to …

[HTML][HTML] Contribution of DNA methylation in chronic stress–induced cardiac remodeling and arrhythmias in mice

P Zhang, T Li, YQ Liu, H Zhang, SM Xue, G Li… - The FASEB …, 2019 - ncbi.nlm.nih.gov
It is recognized that stress can induce cardiac dysfunction, but the underlying mechanisms
are not well understood. The present study aimed to test the hypothesis that chronic …

The influence of lifestyle factors on the occurrence and severity of premature ventricular contractions: a comprehensive review

IM Tungar, MMRK Reddy, SM Flores, P Pokhrel… - Current Problems in …, 2024 - Elsevier
Premature ventricular contractions (PVC) are a type of ventricular arrhythmias, occurring as
a result of formation or reentry of an abnormal impulse in the ventricular myocardium or in …

Of mice and men on MDMA: A translational comparison of the neuropsychobiological effects of 3, 4-methylenedioxymethamphetamine ('Ecstasy')

MA Aguilar, MP García-Pardo, AC Parrott - Brain research, 2020 - Elsevier
Abstract MDMA (3, 4-methylendioxymethamphetamine), also known as Ecstasy, is a
stimulant drug recreationally used by young adults usually in dance clubs and raves. Acute …

Mitochondrial polymerase gamma dysfunction and aging cause cardiac nuclear DNA methylation changes

CA Koczor, I Ludlow, E Fields, Z Jiao… - Physiological …, 2016 - journals.physiology.org
Cardiomyopathy (CM) is an intrinsic weakening of myocardium with contractile dysfunction
and congestive heart failure (CHF). CHF has been postulated to result from decreased …

From the cover: sperm molecular biomarkers are sensitive indicators of testicular injury following subchronic model toxicant exposure

E Dere, SK Wilson, LM Anderson… - Toxicological …, 2016 - academic.oup.com
Traditional testis histopathology endpoints remain the gold standard for evaluating testicular
insult and injury in a non-clinical setting, but are invasive and unfeasible for monitoring …