Beauty and the beast: host microRNA-155 versus SARS-CoV-2

KI Papadopoulos, A Papadopoulou, TC Aw - Human Cell, 2023 - Springer
Severe acute respiratory coronavirus 2 (SARS-CoV-2) infection in the young and healthy
usually results in an asymptomatic or mild viral syndrome, possibly through an erythropoietin …

Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells

Y Zhu, KY Chew, M Wu, AC Karawita, G McCallum… - PLos …, 2022 - journals.plos.org
Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-
19) when compared to adults. There is a strong body of evidence that children are also less …

Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infections

SH Qassim, MR Hasan, P Tang, H Chemaitelly… - Frontiers in …, 2022 - frontiersin.org
In 2021, Qatar experienced considerable incidence of SARS-CoV-2 infection that was
dominated sequentially by the Alpha, Beta, and Delta variants. Using the cycle threshold (Ct) …

Routine SARS‐CoV‐2 vaccination for all children

K De Paris, SR Permar - Immunological reviews, 2022 - Wiley Online Library
The SARS‐CoV‐2 pandemic has resulted in unprecedented health and economic losses.
Children generally present with less severe disease from this virus compared with adults, yet …

Epipharyngeal abrasive therapy down-regulates the expression of SARS-CoV-2 entry factors ACE2 and TMPRSS2

K Nishi, S Yoshimoto, S Nishi, T Tsunoda, J Ohno… - in vivo, 2022 - iv.iiarjournals.org
Background: The epipharynx, with its high expression of Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) entry factors angiotensin-converting enzyme 2 …

One for all—human kidney Caki-1 cells are highly susceptible to infection with corona-and other respiratory viruses

A Daniels, S Fletcher, HEM Kerr, A Kratzel… - Journal of …, 2023 - Am Soc Microbiol
In vitro investigations of host-virus interactions are reliant on suitable cell and tissue culture
models. Results are only as good as the model they are generated in. However, choosing …

HMGB1: a potential target of nervus vagus stimulation in pediatric SARS-CoV-2-induced ALI/ARDS

L Jankauskaite, M Malinauskas… - Frontiers in …, 2022 - frontiersin.org
From the start of pandemics, children were described as the ones who were less affected by
SARS-Cov-2 or COVID-19, which was mild in most of the cases. However, with the growing …

Pediatric nasal epithelial cells are less permissive to SARS-CoV-2 replication compared to adult cells

Y Zhu, KY Chew, AC Karawita, A Yamamoto, LL Labzin… - BioRxiv, 2021 - biorxiv.org
Rationale Young children (typically those< 10 years old) are less susceptible to SARS-CoV-
2 infection and symptoms compared to adults. However, the mechanisms that underlie these …

Mapping ACE2 and TMPRSS2 co-expression in human brain tissue: implications for SARS-CoV-2 neurological manifestations

T Gupta, M Kumar, UJ Kaur, A Rao, R Bharti - Journal of NeuroVirology, 2024 - Springer
Abstract The Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) primarily targets respiratory cells, but emerging …

A protective erythropoietin evolutionary landscape, NLRP3 inflammasome regulation, and multisystem inflammatory syndrome in children

KI Papadopoulos, A Papadopoulou, TC Aw - Human Cell, 2023 - Springer
The low incidence of pediatric severe acute respiratory syndrome coronavirus-2 (SARS-CoV-
2) infection and the associated multisystem inflammatory syndrome (MIS-C) lack a unifying …