Deep brain stimulation for obsessive-compulsive disorder and depression

SA Sheth, HS Mayberg - Annual Review of Neuroscience, 2023 - annualreviews.org
The field of stereotactic neurosurgery developed more than 70 years ago to address a
therapy gap for patients with severe psychiatric disorders. In the decades since, it has …

Closed-loop neurostimulation for the treatment of psychiatric disorders

KK Sellers, JL Cohen, AN Khambhati, JM Fan… - …, 2024 - nature.com
Despite increasing prevalence and huge personal and societal burden, psychiatric diseases
still lack treatments which can control symptoms for a large fraction of patients. Increasing …

Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder

NR Provenza, S Reddy, AK Allam, SV Rajesh, N Diab… - Nature Medicine, 2024 - nature.com
Recent advances in surgical neuromodulation have enabled chronic and continuous
intracranial monitoring during everyday life. We used this opportunity to identify neural …

Deep brain stimulation for obsessive-compulsive disorder: Optimal stimulation sites

GM Meyer, B Hollunder, N Li, K Butenko, TA Dembek… - Biological …, 2024 - Elsevier
Background Deep brain stimulation (DBS) is a promising treatment option for treatment-
refractory obsessive-compulsive disorder (OCD). Several stimulation targets have been …

Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo …

THW Ching, R Grazioplene, C Bohner… - Frontiers in …, 2023 - frontiersin.org
Background Psilocybin may help treat obsessive–compulsive disorder (OCD). To date, only
one open-label study of psilocybin for OCD exists, necessitating further investigation with a …

Future directions in psychiatric neurosurgery: proceedings of the 2022 American Society for Stereotactic and Functional Neurosurgery meeting on surgical …

FL Hitti, AS Widge, P Riva-Posse, DA Malone Jr… - Brain Stimulation, 2023 - Elsevier
Objective. Despite advances in the treatment of psychiatric diseases, currently available
therapies do not provide sufficient and durable relief for as many as 30–40% of patients …

A meta-analysis of transcranial magnetic stimulation in obsessive-compulsive disorder

ER Steuber, JF McGuire - Biological Psychiatry: Cognitive Neuroscience …, 2023 - Elsevier
Background Obsessive-compulsive disorder (OCD) is a debilitating illness with substantial
morbidity. Although pharmacological and behavioral evidence–based treatments have …

Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics …

JK Wong, HS Mayberg, DD Wang… - Frontiers in Human …, 2023 - frontiersin.org
The deep brain stimulation (DBS) Think Tank X was held on August 17–19, 2022 in Orlando
FL. The session organizers and moderators were all women with the theme women in …

Network Analysis of Cognitive-Behavioral Symptom Connectivity in OCD Subtypes: Evaluating SSRI Treatment Response and Resistance

M Davoudi, RM Abdelrahman, A Fakhrou… - Cognitive Therapy and …, 2024 - Springer
Background This study employed network analysis to predict treatment responses, focusing
on obsessive beliefs and symptoms within the contamination/cleaning and danger/checking …

Network targets for therapeutic brain stimulation: towards personalized therapy for pain

JC Motzkin, I Kanungo, M D'Esposito… - Frontiers in pain …, 2023 - frontiersin.org
Precision neuromodulation of central brain circuits is a promising emerging therapeutic
modality for a variety of neuropsychiatric disorders. Reliably identifying in whom, where, and …