Recent developments on the potential biological applications of transition metal complexes of thiosemicarbazone derivatives

V Singh, VNV Palakkeezhillam, V Manakkadan… - Polyhedron, 2023 - Elsevier
This review talks about the synthesis, and coordination chemistry of thiosemicarbazone and
its bonding with transition metals like copper, nickel, zinc, palladium, and ruthenium and …

Recent advances in drug discovery against Mycobacterium tuberculosis: Metal-based complexes

CB Scarim, RL de Farias, AV de Godoy Netto… - European Journal of …, 2021 - Elsevier
Metal-based drugs are privileged motifs that act as primary pharmacophores in bioactive
compounds for various diseases, including tuberculosis (TB). This potentially life-threatening …

[PDF][PDF] Trace minerals in human health: Iron, zinc, copper, manganese and fluorine

CS Silva, C Moutinho, A Ferreira da Vinha… - International Journal of …, 2019 - bdigital.ufp.pt
Trace elements exist in the environment in small amounts but play an essential part in
sustaining various physiological and metabolic processes occurring within living tissues, as …

In Silico Strategies in Tuberculosis Drug Discovery

SJY Macalino, JB Billones, VG Organo, MCO Carrillo - Molecules, 2020 - mdpi.com
Tuberculosis (TB) remains a serious threat to global public health, responsible for an
estimated 1.5 million mortalities in 2018. While there are available therapeutics for this …

Platinum (II) and Ruthenium (II) complexes in medicine: Antimycobacterial and Anti-HIV activities

DM Yufanyi, HS Abbo, SJJ Titinchi, T Neville - Coordination Chemistry …, 2020 - Elsevier
Approximately 100 million people worldwide are affected by M. Tuberculosis (Mtb), a
contagious disease which causes death in humans and is considered to be quite deadly …

Copper (II) complexes based on thiosemicarbazone ligand: Preparation, crystal structure, Hirshfeld surface, energy framework, antiMycobacterium activity, in silico …

RAC Souza, WRP Costa, EF Faria, MAS Bessa… - Journal of Inorganic …, 2021 - Elsevier
Considering the promising previous results on the remarkable activity exhibited by cobalt (III)
and manganese (II) thiosemicarbazone compounds as antibacterial agents, the present …

Zinc (II) complexes bearing N, N, S ligands: Synthesis, crystal structure, spectroscopic analysis, molecular docking and biological investigations about its antifungal …

RAC Souza, VL Cunha, JH de Souza… - Journal of Inorganic …, 2022 - Elsevier
In the present work, the synthesis, characterization, antifungal activity, molecular docking
study and in silico approach of five thiosemicarbazone derivatives and their corresponding …

5-Methoxyisatin N (4)-Pyrrolidinyl Thiosemicarbazone (MeOIstPyrd) Restores Mutant p53 and Inhibits the Growth of Skin Cancer Cells, In Vitro

N Shahi, PN Yadav, U Chaudhary, M Saad… - ACS …, 2023 - ACS Publications
A series of novel thiosemicarbazone derivatives containing 5-methoxy isatin were designed
and synthesized with modification on N (4) position. Derivatives considering structure …

Novel tetranuclear Pd II and Pt II anticancer complexes derived from pyrene thiosemicarbazones

CG Oliveira, I Romero-Canelón, JPC Coverdale… - Dalton …, 2020 - pubs.rsc.org
Cyclometallated palladium (II) and platinum (II) pyrenyl-derived thiosemicarbazone (H2PrR)
complexes of the type [M4 (μ-S-PrR-κ3-C, N, S) 4](M= PdII, PtII; R= ethyl, cyclohexyl) have …

Drug Discovery for Mycobacterium tuberculosis Using Structure-Based Computer-Aided Drug Design Approach

MA Ejalonibu, SA Ogundare, AA Elrashedy… - International Journal of …, 2021 - mdpi.com
Developing new, more effective antibiotics against resistant Mycobacterium tuberculosis that
inhibit its essential proteins is an appealing strategy for combating the global tuberculosis …