Predicting cross-reactivity and antigen specificity of T cell receptors
Adaptive immune recognition is mediated by specific interactions between heterodimeric T
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients
SK Saini, DS Hersby, T Tamhane, HR Povlsen… - Science …, 2021 - science.org
T cells are important for effective viral clearance, elimination of virus-infected cells, and long-
term disease protection. To examine the full spectrum of CD8+ T cell immunity in COVID-19 …
term disease protection. To examine the full spectrum of CD8+ T cell immunity in COVID-19 …
Structural basis for T cell recognition of cancer neoantigens and implications for predicting neoepitope immunogenicity
Adoptive cell therapy (ACT) with tumor-specific T cells has been shown to mediate durable
cancer regression. Tumor-specific T cells are also the basis of other therapies, notably …
cancer regression. Tumor-specific T cells are also the basis of other therapies, notably …
Defining and studying B cell receptor and TCR interactions
CG Rappazzo, ML Fernández-Quintero… - The Journal of …, 2023 - journals.aai.org
Abstract BCRs (Abs) and TCRs (or adaptive immune receptors [AIRs]) are the means by
which the adaptive immune system recognizes foreign and self-antigens, playing an integral …
which the adaptive immune system recognizes foreign and self-antigens, playing an integral …
Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen
Adoptive cell therapy (ACT) with tumor-specific T cells can mediate cancer regression. The
main target of tumor-specific T cells are neoantigens arising from mutations in self-proteins …
main target of tumor-specific T cells are neoantigens arising from mutations in self-proteins …
A systematic safety pipeline for selection of T-cell receptors to enter clinical use
Z Foldvari, C Knetter, W Yang, TJ Gjerdingen… - npj Vaccines, 2023 - nature.com
Cancer immunotherapy using T cell receptor-engineered T cells (TCR-Ts) represents a
promising treatment option. However, technologies for pre-clinical safety assessment are …
promising treatment option. However, technologies for pre-clinical safety assessment are …
The anticancer potential of T cell receptor-engineered T cells
M Ecsedi, MS McAfee, AG Chapuis - Trends in cancer, 2021 - cell.com
Adoptively transferred T cell receptor (TCR)-transgenic T cells (TCR-T cells) are not
restricted by cell surface expression of their targets and are therefore poised to become a …
restricted by cell surface expression of their targets and are therefore poised to become a …
CD8 T cell function and cross-reactivity explored by stepwise increased peptide-HLA versus TCR affinity
P Baumgaertner, J Schmidt, CM Costa-Nunes… - Frontiers in …, 2022 - frontiersin.org
Recruitment and activation of CD8 T cells occur through specific triggering of T cell receptor
(TCR) by peptide-bound human leucocyte antigen (HLA) ligands. Within the generated …
(TCR) by peptide-bound human leucocyte antigen (HLA) ligands. Within the generated …
A robust deep learning workflow to predict CD8+ T-cell epitopes
Background T-cells play a crucial role in the adaptive immune system by triggering
responses against cancer cells and pathogens, while maintaining tolerance against self …
responses against cancer cells and pathogens, while maintaining tolerance against self …
T cell receptors employ diverse strategies to target a p53 cancer neoantigen
Adoptive cell therapy with tumor-specific T cells can mediate durable cancer regression. The
prime target of tumor-specific T cells are neoantigens arising from mutations in self-proteins …
prime target of tumor-specific T cells are neoantigens arising from mutations in self-proteins …