Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been
the most widely used excipients for the stabilization of protein therapeutics for years. In …

Ionic liquids (ILs) have recently emerged as versatile solvents and additives in the field of
biotechnology, particularly as stabilizers of proteins and enzymes. Of interest to the …

Cytokines are messenger proteins that regulate the proliferation and differentiation of cells
and control immune responses. Interferons, interleukins, and growth factors have …

Ionic liquids are salts in which the ions are poorly coordinated, which causes them to exist in
liquid form below 100 C, or at room temperature. Therefore, these are also defined as room …

The emergence of biopharmaceuticals, including proteins, nucleic acids, peptides, and
vaccines, revolutionized the medical field, contributing to significant advances in the …

We investigated the effect of an emerging biocompatible ionic liquid, choline dihydrogen
phosphate (CDHP), on the stability of high-concentration formulations of Herceptin® …

Rutin is a known antioxidant compound that displays a broad range of biological activities
and health-related benefits but presents a low water solubility that can be overcome by its …

Phase transitions, isobaric heat capacities and thermal stability of four ionic liquids (ILs) are
determined in this work. The selected Ionic Liquids (ILs) have two different cations …

Cross-linkers aid in improving biostability of collagen via different mechanisms. Choline
dihydrogen phosphate (cDHP), a biocompatible ionic liquid, has been reported as a …

We report substantially enhanced biological stability of siRNA in a hydrated ionic liquid (IL)
based on buffered choline dihydrogen phosphate (CDP). The results show that hydrated …