Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

Mast cells in neuroinflammation and brain disorders

E Hendriksen, D van Bergeijk, RS Oosting… - Neuroscience & …, 2017 - Elsevier
It is well recognized that neuroinflammation is involved in the pathogenesis of various
neurodegenerative diseases. Microglia and astrocytes are major pathogenic components …

Key role of DAMP in inflammation, cancer, and tissue repair

F Pandolfi, S Altamura, S Frosali, P Conti - Clinical therapeutics, 2016 - Elsevier
Purpose This review aimed to take stock of the current status of research on damage-
associated molecular pattern (DAMP) protein. We discuss the Janus-faced role of DAMP …

Recent advances in our understanding of mast cell activation–or should it be mast cell mediator disorders?

TC Theoharides, I Tsilioni, H Ren - Expert review of clinical …, 2019 - Taylor & Francis
Introduction: An increasing number of patients present with multiple symptoms affecting
many organs including the brain due to multiple mediators released by mast cells. These …

Activation of mast cells by neuropeptides: the role of pro-inflammatory and anti-inflammatory cytokines

D Lauritano, F Mastrangelo, C D'Ovidio… - International journal of …, 2023 - mdpi.com
Mast cells (MCs) are tissue cells that are derived from bone marrow stem cells that
contribute to allergic reactions, inflammatory diseases, innate and adaptive immunity …

Mast cell activation: beyond histamine and tryptase

TC Theoharides, AI Perlman, A Twahir… - Expert Review of …, 2023 - Taylor & Francis
Introduction Mast cells are found in all tissues and express numerous surface receptors
allowing them to sense and respond to allergic, autoimmune, environmental …

The impact of psychological stress on mast cells

TC Theoharides - Annals of Allergy, Asthma & Immunology, 2020 - Elsevier
Objective Atopic diseases worsen with psychological stress, but how stress contributes to
their pathogenesis is still not clear. We review the evidence supporting the premise that …

Mast cells in the autonomic nervous system and potential role in disorders with dysautonomia and neuroinflammation

TC Theoharides, A Twahir, D Kempuraj - Annals of Allergy, Asthma & …, 2024 - Elsevier
Mast cells (MC) are ubiquitous in the body, and they are critical for not only in allergic
diseases but also in immunity and inflammation, including having potential involvement in …

[HTML][HTML] Clinical potential of immunotherapies in Subarachnoid Hemorrhage Treatment: mechanistic dissection of Innate and Adaptive Immune responses

A Zhang, Y Liu, X Wang, H Xu, C Fang, L Yuan… - Aging and …, 2023 - ncbi.nlm.nih.gov
Subarachnoid hemorrhage (SAH), classified as a medical emergency, is a devastating and
severe subtype of stroke. SAH induces an immune response, which further triggers brain …

Towards molecular classification of meningioma: evolving treatment and diagnostic paradigms

DT Proctor, S Ramachandran, S Lama… - World neurosurgery, 2018 - Elsevier
Highlights•WHO grading of meningioma may not reflect tumor biology.•Molecular
characterization of meningioma may more closely correlate to tumor biology.•Genetic …