Acute spinal cord injury: Pathophysiology and pharmacological intervention
Y Zhang, A Al Mamun, Y Yuan… - Molecular …, 2021 - spandidos-publications.com
Spinal cord injury (SCI) is one of the most debilitating of all the traumatic conditions that
afflict individuals. For a number of years, extensive studies have been conducted to clarify …
afflict individuals. For a number of years, extensive studies have been conducted to clarify …
The immune microenvironment and tissue engineering strategies for spinal cord regeneration
Y Feng, Y Peng, J Jie, Y Yang, P Yang - Frontiers in Cellular …, 2022 - frontiersin.org
Regeneration of neural tissue is limited following spinal cord injury (SCI). Successful
regeneration of injured nerves requires the intrinsic regenerative capability of the neurons …
regeneration of injured nerves requires the intrinsic regenerative capability of the neurons …
Development and optimization of Riluzole-loaded biodegradable nanoparticles incorporated in a mucoadhesive in situ gel for the posterior eye segment
G Esteruelas, L Halbaut, V Garcia-Torra… - International Journal of …, 2022 - Elsevier
Riluzole-loaded PLGA nanoparticles (RLZ-NPs) were developed to improve the
biopharmaceutical profile of RLZ after ocular administration. Moreover, RLZ-NPs were …
biopharmaceutical profile of RLZ after ocular administration. Moreover, RLZ-NPs were …
Methylprednisolone induces neuro-protective effects via the inhibition of A1 astrocyte activation in traumatic spinal cord injury mouse models
H Zou, SW Guo, L Zhu, X Xu, J Liu - Frontiers in Neuroscience, 2021 - frontiersin.org
Traumatic spinal cord injury (TSCI) leads to pathological changes such as inflammation,
edema, and neuronal apoptosis. Methylprednisolone (MP) is a glucocorticoid that has a …
edema, and neuronal apoptosis. Methylprednisolone (MP) is a glucocorticoid that has a …
Therapeutic effect of metformin on inflammation and apoptosis after spinal cord injury in rats through the Wnt/β-catenin signaling pathway
T Zhang, F Wang, K Li, C Lv, K Gao, C Lv - Neuroscience Letters, 2020 - Elsevier
Objective To verify the effect of metformin on spinal cord injury (SCI) through Wnt/β-catenin
signaling pathway. Background SCI is a serious traumatic disease of the central nervous …
signaling pathway. Background SCI is a serious traumatic disease of the central nervous …
An oil-in-gel type of organohydrogel loaded with methylprednisolone for the treatment of secondary injuries following spinal cord traumas
Y Tan, T Lai, Y Li, Q Tang, W Zhang, Q Liu, S Wu… - Journal of Controlled …, 2024 - Elsevier
The secondary injuries following traumatic spinal cord injury (SCI) is a multiphasic and
complex process that is difficult to treat. Although methylprednisolone (MP) is the only …
complex process that is difficult to treat. Although methylprednisolone (MP) is the only …
Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model
S Xiao, N Zhong, Q Yang, A Li, W Tong, Y Zhang… - International …, 2022 - Elsevier
Background Spinal cord injury (SCI) can cause severe motor impairment. Post-SCI treatment
has focused primarily on secondary injury, with neuroinflammation and neuronal apoptosis …
has focused primarily on secondary injury, with neuroinflammation and neuronal apoptosis …
Nerve growth factor loaded macrophage-derived nanovesicles for inhibiting neuronal apoptosis after spinal cord injury
N Xia, Z Gao, H Hu, D Li, C Zhang… - Journal of …, 2021 - journals.sagepub.com
Spinal cord injury (SCI) is an extremely destructive central nervous system lesion. Studies
have shown that NGF can promote nerve regeneration after SCI. However, it cannot produce …
have shown that NGF can promote nerve regeneration after SCI. However, it cannot produce …
Novel therapeutic effects in rat spinal cord injuries: Recovery of the definitive and early spinal cord injury by the administration of pentadecapeptide BPC 157 therapy
Recently, marked therapeutic effects pertaining to the recovery of injured rat spinal cords (1
min compression injury of the sacrocaudal spinal cord (S2-Co1) resulting in tail paralysis) …
min compression injury of the sacrocaudal spinal cord (S2-Co1) resulting in tail paralysis) …
Advancing Recovery Post‐Spinal Cord Injury: Nanoparticle‐Mediated Reprogramming of Peripheral Macrophages
J Liu, D Liu, R Ma, Z Ma, Z Peng… - Advanced Functional …, 2024 - Wiley Online Library
Spinal cord injuries (SCIs) often result in secondary damage; therefore, interventions
beyond current cell transplantation methods must be explored. The innate phagocytic …
beyond current cell transplantation methods must be explored. The innate phagocytic …