Ionizable lipids with branched tails have been used in lipid nanoparticles (LNPs)‐based
messenger RNA (mRNA) therapeutics like COVID‐19 vaccines. However, due to the limited …

For the continuation and evolution of life, primitive membranes formed from prebiotically
available components must have fulfilled certain essential requirements. Candidate …

Most phospholipids constituting biological membranes are chiral molecules with a
hydrophilic head group and hydrophobic alkyl chains, rendering biphasic property …

The chain melting of lipid bilayers has often been investigated in detail using calorimetric
methods, such as differential scanning calorimetry (DSC), and the resultant main transition …

The exposure of mRNA to water is likely to contribute to the instability of RNA vaccines upon
storage under nonfrozen conditions. Using atomistic molecular dynamics (MD) simulations …

In this review, we deal with the flexible structures of small biomolecules and discuss how
spontaneous conformational changes are related to their biological functions, mainly …

Diphytanoylphosphatidylcholine (DPhPC) is a synthetic phospholipid in which two methyl-
branched acyl chains are introduced into the glycerol moiety, mimicking phospholipids of …

Membrane Proteins (MPs) constitute the majority of developed drug targets, and our ability
to satisfactorily investigate membrane proteins is paramount to a variety of areas within …

PEG polyethyleneglycol Ψ pseudouridine RIG-I retinoic acid inducible gene-I ROI region of
interest SD standard deviation Sec second siRNA short interference RNA SNALP stable …