Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central
nervous system, being expressed in neurons and non-neuronal cells, where they participate …

Mammalian spermatogenesis is a complex biological process occurring in the seminiferous
tubules in the testis. This process represents a delicate balance between cell proliferation …

Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is an important part of the cholinergic
nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory …

Background Neuroinflammation plays an important role in the pathogenesis of intracerebral
hemorrhage (ICH)-induced secondary brain injury. Activation of melanocortin receptor 4 …

Critical illnesses and injuries are recognized as major threats to human health, and they are
usually accompanied by uncontrolled inflammation and dysfunction of immune response …

Background and Purpose Inflammasome‐mediated pyroptosis is an important neuronal cell
death mechanism. Previous studies reported that activation of melanocortin MC4 receptor …

Postoperative ileus (POI) after abdominal surgery significantly lowers the life quality of
patients and increase hospital costs. However, few treatment strategies have successfully …

Melanocortins exert neuroprotection in a variety of experimental neurodegenerative
disorders, including Alzheimer's disease (AD). Further, in previous research we showed that …

Melanocortin peptides induce neuroprotection in acute and chronic experimental
neurodegenerative conditions. Melanocortins likewise counteract systemic responses to …

To date, available treatment strategies for multiple sclerosis (MS) are ineffective in
preventing or reversing progressive neurologic deterioration, creating a high, and unmet …