This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Dihydroxyvitamin D3 [1, 25 (OH) 2D3], the biologically active form of vitamin D3, is a
secosteroid hormone essential for bone and mineral homeostasis. It regulates the growth …

Abstract Approximately 30%-50% of people are recognized to have low levels of vitamin D,
and insufficiency and deficiency of vitamin D are recognized as global health problems …

Impaired vitamin D status is common to many populations around the world. However, data
suggest that this is a particular problem for specific groups such as pregnant women. This …

The high affinity folate receptor is a membrane‐associated glycoprotein that is preferentially
expressed in cancers of epithelial origin and rarely expressed in normal cells. We examined …

Aberrant activation of the Wnt/β-catenin pathway is critical for the initiation and progression
of most colon cancers. This activation provokes the accumulation of nuclear β-catenin and …

Cholestasis results in intrahepatic accumulation of cytotoxic bile acids, which cause liver
damage ultimately leading to biliary fibrosis and cirrhosis. Cholestatic liver injury is …

Colorectal cancer is a major health problem worldwide. Aberrant activation of the Wingless-
type mouse mammary tumour virus integration site family (Wnt)/β-catenin signalling pathway …

1, 25-dihydroxyvitamin D3 affects proliferation, differentiation, and apoptosis and protects
DNA against oxidative damage with a net tumorostatic and anticarcinogenic effect. It acts …

Nuclear Receptors as Drug Targets in Cholestatic Liver Diseases - Clinics in Liver Disease
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