Lipid nanoparticle–mRNA formulations for therapeutic applications
Conspectus After decades of extensive fundamental studies and clinical trials, lipid
nanoparticles (LNPs) have demonstrated effective mRNA delivery such as the Moderna and …
nanoparticles (LNPs) have demonstrated effective mRNA delivery such as the Moderna and …
The endosomal escape of nanoparticles: toward more efficient cellular delivery
SA Smith, LI Selby, APR Johnston… - Bioconjugate …, 2018 - ACS Publications
Many emerging therapies rely on the delivery of biological cargo into the cytosol.
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …
Small RNAs–big players in plant-microbe interactions
Eukaryotic small RNAs (sRNAs) are short non-coding regulatory molecules that induce RNA
interference (RNAi). During microbial infection, host RNAi machinery is highly regulated and …
interference (RNAi). During microbial infection, host RNAi machinery is highly regulated and …
Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
C Xue, S Hu, ZH Gao, L Wang, MX Luo, X Yu… - Nature …, 2021 - nature.com
Small interfering RNA (siRNA) is an effective therapeutic to regulate the expression of target
genes in vitro and in vivo. Constructing a siRNA delivery system with high serum stability …
genes in vitro and in vivo. Constructing a siRNA delivery system with high serum stability …
Small RNAs and extracellular vesicles: New mechanisms of cross-species communication and innovative tools for disease control
Small RNA (sRNA)-mediated RNA interference (RNAi) is a conserved regulatory
mechanism for gene expression throughout the domain Eukarya. Recent studies have …
mechanism for gene expression throughout the domain Eukarya. Recent studies have …
Self-assembly of stem cell membrane-camouflaged nanocomplex for microRNA-mediated repair of myocardial infarction injury
C Yao, W Wu, H Tang, X Jia, J Tang, X Ruan, F Li… - Biomaterials, 2020 - Elsevier
Mesenchymal stem cells-derived exosomes have shown promising therapeutic effect on
myocardial infarction (MI). The major hurdles remain for the use of exosomes primarily due …
myocardial infarction (MI). The major hurdles remain for the use of exosomes primarily due …
α-Amino acid N-carboxyanhydride (NCA)-derived synthetic polypeptides for nucleic acids delivery
In recent years, gene therapy has come into the spotlight for the prevention and treatment of
a wide range of diseases. Polypeptides have been widely used in mediating nucleic acid …
a wide range of diseases. Polypeptides have been widely used in mediating nucleic acid …
Regenerative approaches for chronic wounds
F Berthiaume, HC Hsia - Annual Review of Biomedical …, 2022 - annualreviews.org
Chronic skin wounds are commonly found in older individuals who have impaired circulation
due to diabetes or are immobilized due to physical disability. Chronic wounds pose a severe …
due to diabetes or are immobilized due to physical disability. Chronic wounds pose a severe …
3D microfluidic platform and tumor vascular mapping for evaluating anti-angiogenic RNAi-based nanomedicine
Three-dimensional (3D) visualization of tumor vasculature is a key factor in accurate
evaluation of RNA interference (RNAi)-based antiangiogenic nanomedicine, a promising …
evaluation of RNA interference (RNAi)-based antiangiogenic nanomedicine, a promising …
Bioinspired and biomimetic gene delivery systems
M Tuyen Ho, A Barrett, Y Wang, Q Hu - ACS Applied Bio Materials, 2023 - ACS Publications
Gene therapy that can introduce, counteract, or replace genes possesses great potential to
address diseases at their genetic roots. A wide range of technologies, such as RNA …
address diseases at their genetic roots. A wide range of technologies, such as RNA …