Safety and efficacy of subcutaneous ianalumab (VAY736) in patients with primary Sjögren's syndrome: a randomised, double-blind, placebo-controlled, phase 2b …
Background Sjögren's syndrome is an autoimmune disease characterised by dry eyes and
mouth, systemic features, and reduced quality of life. There are no disease-modifying …
mouth, systemic features, and reduced quality of life. There are no disease-modifying …
Filgotinib versus placebo or adalimumab in patients with rheumatoid arthritis and inadequate response to methotrexate: a phase III randomised clinical trial
Objective To evaluate the efficacy and safety of the Janus kinase-1-preferential inhibitor
filgotinib versus placebo or tumour necrosis factor-α inhibitor therapy in patients with active …
filgotinib versus placebo or tumour necrosis factor-α inhibitor therapy in patients with active …
Efficacy and safety of tildrakizumab in patients with active psoriatic arthritis: results of a randomised, double-blind, placebo-controlled, multiple-dose, 52-week phase …
PJ Mease, S Chohan, FJG Fructuoso… - Annals of the …, 2021 - ard.bmj.com
Objectives To evaluate efficacy and safety of the anti-interleukin-23p19 monoclonal antibody
tildrakizumab in patients with psoriatic arthritis (PsA). Methods In this randomised, double …
tildrakizumab in patients with psoriatic arthritis (PsA). Methods In this randomised, double …
Frunevetmab, a felinized anti‐nerve growth factor monoclonal antibody, for the treatment of pain from osteoarthritis in cats
ME Gruen, JAE Myers, JKS Tena… - Journal of Veterinary …, 2021 - Wiley Online Library
Background Frunevetmab, a felinized antinerve growth factor monoclonal antibody,
effectively decreases osteoarthritis (OA) pain in cats. Objective To evaluate the efficacy of …
effectively decreases osteoarthritis (OA) pain in cats. Objective To evaluate the efficacy of …
Effects of N-acetylcysteine supplementation on disease activity, oxidative stress, and inflammatory and metabolic parameters in rheumatoid arthritis patients: a …
K Esalatmanesh, A Jamali, R Esalatmanesh… - Amino Acids, 2022 - Springer
Considering the importance of inflammation and oxidative stress in the development of
rheumatoid arthritis (RA) as well as anti-inflammatory and antioxidant features of N …
rheumatoid arthritis (RA) as well as anti-inflammatory and antioxidant features of N …
Assessment of placebo response in objective and subjective outcome measures in rheumatoid arthritis clinical trials
Importance Large placebo responses in randomized clinical trials may keep effective
medication from reaching the market. Primary outcome measures of clinical trials have …
medication from reaching the market. Primary outcome measures of clinical trials have …
CD40 ligand antagonist dazodalibep in Sjögren's disease: a randomized, double-blinded, placebo-controlled, phase 2 trial
EW St. Clair, AN Baer, WF Ng, G Noaiseh, C Baldini… - Nature Medicine, 2024 - nature.com
Sjögren's disease (SjD) is a chronic, systemic autoimmune disease with no approved
disease-modifying therapies. Dazodalibep (DAZ), a novel nonantibody fusion protein, is a …
disease-modifying therapies. Dazodalibep (DAZ), a novel nonantibody fusion protein, is a …
The response to TNF blockers depending on their comparator in rheumatoid arthritis clinical trials: the lessebo effect, a meta-analysis
L Lopez, R Griffier, T Barnetche, E Lhomme… - …, 2022 - academic.oup.com
Objective To compare the effect of the biological reference agents (infliximab, etanercept,
adalimumab) in RA in pivotal superiority placebo-controlled trials (reference agent vs …
adalimumab) in RA in pivotal superiority placebo-controlled trials (reference agent vs …
Placebo response in psoriatic arthritis clinical trials: a systematic review and meta-analysis
Objective To determine the placebo response rate in PsA randomized clinical trials (RCTs),
its contributing factors and impact on the effect size of active treatments. Methods We …
its contributing factors and impact on the effect size of active treatments. Methods We …
Gulf war illness inflammation reduction trial: A phase 2 randomized controlled trial of low-dose prednisone chronotherapy, effects on health-related quality of life
RR Bach, RR Rudquist - Plos one, 2023 - journals.plos.org
Background Gulf War illness (GWI) is a deployment-related chronic multisymptom illness
impacting the health-related quality of life (HRQOL) of many US Military Veterans of the …
impacting the health-related quality of life (HRQOL) of many US Military Veterans of the …