Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …

Simple Summary The IL-12 family cytokines play an important role in regulating the tumor
immune contexture. Recent efforts geared towards the development of better immune …

Immunotherapy of cancer has made tremendous progress in recent years, as demonstrated
by the remarkable clinical responses obtained from adoptive cell transfer (ACT) of patient …

T cells follow a triphasic distinct pathway of activation, proliferation and differentiation before
becoming functionally and phenotypically “exhausted” in settings of chronic infection …

Oral cancers are among the common head and neck malignancies. Different anticancer
therapy modalities such as chemotherapy, immunotherapy, radiation therapy, and also …

Elevated levels of IL-10 in the microenvironment of human ovarian cancer and murine
models of ovarian cancer are well established and correlate with poor clinical prognosis …

The genetic modification of CD8+ T cells using anti-tumor T-cell receptors (TCR) or chimeric
antigen receptors is a promising approach for the adoptive cell therapy of patients with …

Adoptive cellular therapy (ACT) is a form of immunotherapy whereby antigen-specific T cells
are isolated or engineered, expanded ex vivo, and transferred back to patients. Clinical …

Intratumoral electroporation-mediated IL-12 gene therapy (IT-pIL12/EP) has been shown to
be safe and effective in clinical trials, demonstrating systemic antitumor effects with local …

Immune responses against cancer are dominated by T cell exhaustion and dysfunction.
Recent advances have underscored the critical role of early priming interactions in …