Mosquito-borne diseases present a significant threat to human health, with the possibility of
outbreaks of new mosquito-borne diseases always looming. Unfortunately, current …

Gene drive-modified mosquitoes (GDMMs) are being developed as possible new tools to
prevent transmission of malaria and other mosquito-borne diseases. To date no GDMMs …

Recent experiments have produced several Anopheles gambiae homing gene drives that
disrupt female fertility genes, thereby eventually inducing population collapse. Such drives …

CRISPR homing gene drives can suppress pest populations by targeting female fertility
genes, converting wild-type alleles into drive alleles in the germline of drive heterozygotes …

Mosquito-borne diseases, such as dengue and malaria, pose a significant burden to global
health. Current control strategies with insecticides are only moderately effective. Scalable …

Engineered gene drives, which bias their own inheritance to increase in frequency in target
populations, are being developed to control mosquito malaria vectors. Such mosquitoes can …

Genetic control strategies such as the sterile insect technique have successfully fought
insect pests worldwide. The CRISPR (clustered regularly interspaced short palindromic …

Background Understanding genome organization and evolution is important for species
involved in transmission of human diseases, such as mosquitoes. Anophelinae and …

Wolbachia are maternally-inherited bacteria, which can spread rapidly in populations by
manipulating reproduction. cifA and cifB are genes found in Wolbachia phage that are …

Background Homing gene drives hold great promise for the genetic control of natural
populations. However, current homing systems are capable of spreading uncontrollably …