Core-binding factors (CBFs) are a class of haematopoietic transcription factors that are
crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation …

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic neoplasm which results in
clonal proliferation of abnormally differentiated hematopoietic cells. In this review …

We have assembled a nonredundant set of 144 protein–protein complexes that have high‐
resolution structures available for both the complexes and their unbound components, and …

The core binding factor (CBF) heterodimeric transcription factors comprised of
AML/CBFA/PEBP2α/Runx and CBFβ/PEBP2β subunits are essential for differentiation of …

The RUNX family genes are the mammalian homologs of the Drosophila genes runt and
lozenge, and members of this family function as master regulators of definitive …

Colorectal cancer liver metastasis (CRCLM) has two major histopathological growth
patterns: angiogenic desmoplastic and non-angiogenic replacement. The replacement …

Transcription factors have traditionally been viewed with skepticism as viable drug targets,
but they offer the potential for completely novel mechanisms of action that could more …

Inversion (16) is one of the most frequent chromosomal translocations found in acute
myeloid leukemia (AML), occurring in over 8% of AML cases. This translocation results in a …

Core binding factor (CBF) leukemias, those with translocations or inversions that affect
transcription factor genes RUNX1 or CBFB, account for∼ 24% of adult acute myeloid …

Acute myeloid leukemia (AML) associated translocations often cause gene fusions that
encode oncofusion proteins. Although many of the breakpoints involved in chromosomal …