Acyl-CoA: diacylglycerol acyltransferase (DGAT, EC 2.3. 1.20) catalyzes the last reaction in
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …

The diversity of glycerophospholipid species in cellular membranes is immense and affects
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …

Triacylglycerols (TAGs) are the main source of stored energy in the body, providing an
important substrate pool for mitochondrial beta-oxidation. Imbalances in the amount of TAGs …

Respiratory complex I is a~ 1-MDa proton pump in mitochondria. Its structure has been
revealed in great detail, but the structural basis of its assembly, in humans involving at least …

The number of double bonds in the acyl chains of membrane lipids varies tremendously at
all scales of life, from the organism level to the subcellular level, where differences in lipid …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

We report on the existence of two phosphatidic acid biosynthetic pathways in mycobacteria,
a classical one wherein the acylation of the sn-1 position of glycerol-3-phosphate (G3P) …

Branched-chain amino acids (primarily isoleucine) are important regulators of virulence and
are converted to precursor molecules used to initiate fatty acid synthesis in Staphylococcus …

Monotopic membrane proteins, classified by topology, are proteins that embed into a single
face of the membrane. These proteins are generally underrepresented in the Protein Data …

Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic cell membranes.
In eukaryotes, two highly homologous enzymes, cholinephosphotransferase-1 (CHPT1) and …