Roles of Porphyromonas gingivalis and its virulence factors in periodontitis

W Xu, W Zhou, H Wang, S Liang - Advances in protein chemistry and …, 2020 - Elsevier
Periodontitis is an infection-driven inflammatory disease, which is characterized by gingival
inflammation and bone loss. Periodontitis is associated with various systemic diseases …

Host response mechanisms in periodontal diseases

N Silva, L Abusleme, D Bravo, N Dutzan… - Journal of Applied Oral …, 2015 - SciELO Brasil
Periodontal diseases usually refer to common inflammatory disorders known as gingivitis
and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm …

A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans

N Dutzan, T Kajikawa, L Abusleme… - Science translational …, 2018 - science.org
Periodontitis is one of the most common human inflammatory diseases, yet the mechanisms
that drive immunopathology and could be therapeutically targeted are not well defined …

Inflammatory and immune pathways in the pathogenesis of periodontal disease

A Cekici, A Kantarci, H Hasturk… - Periodontology …, 2014 - Wiley Online Library
The pathogenesis of periodontitis involves a complex immune/inflammatory cascade that is
initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility …

Basic biology and role of interleukin‐17 in immunity and inflammation

C Zenobia, G Hajishengallis - Periodontology 2000, 2015 - Wiley Online Library
Interleukin‐17 (also known as interleukin‐17A) is a key cytokine that links T‐cell activation to
neutrophil mobilization and activation. As such, interleukin‐17 can mediate protective innate …

Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response

G Hajishengallis - Trends in immunology, 2014 - cell.com
Recent studies have uncovered novel mechanisms underlying the breakdown of periodontal
host–microbe homeostasis, which can precipitate dysbiosis and periodontitis in susceptible …

Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later

G Hajishengallis, JM Korostoff - Periodontology 2000, 2017 - Wiley Online Library
In their classic 1976 paper, Page & Schroeder described the histopathologic events and the
types of myeloid cells and lymphocytes involved in the initiation and progression of …

Maintaining homeostatic control of periodontal bone tissue

JD Hathaway‐Schrader, CM Novince - Periodontology 2000, 2021 - Wiley Online Library
Alveolar bone is a unique osseous tissue due to the proximity of dental plaque biofilms.
Periodontal health and homeostasis are mediated by a balanced host immune response to …

Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints

GP Garlet - Journal of dental research, 2010 - journals.sagepub.com
Periodontal diseases (PD) are chronic infectious inflammatory diseases characterized by the
destruction of tooth-supporting structures, being the presence of periodontopathogens …

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss

MA Eskan, R Jotwani, T Abe, J Chmelar, JH Lim… - Nature …, 2012 - nature.com
Aging is linked to greater susceptibility to chronic inflammatory diseases, several of which,
including periodontitis, involve neutrophil-mediated tissue injury. Here we found that aging …