Decreased skeletal muscle contractile activity (disuse) or unloading leads to muscle mass
loss, also known as muscle atrophy. The balance between muscle protein synthesis (MPS) …

Metformin is a widely accepted first-line hypoglycemic agent in current clinical practice, and
it has been applied to the clinic for more than 60 years. Recently, researchers have …

Muscle inflammation and fibrosis underlie disuse‐related complications and may contribute
to impaired muscle recovery in aging. Cellular senescence is an emerging link between …

Branched‐chain amino acids (BCAA) are essential in the diet and promote several vital cell
responses which may have benefits for health and athletic performance, as well as disease …

We determined if skeletal muscle extracellular matrix (ECM) content and remodeling
markers adapted with resistance training or were associated with hypertrophic outcomes …

Purpose The two structural components contributing to joint contracture formation are
myogenic and arthrogenic contracture, and myofibrosis is an important part of myogenic …

Background Metabolic diseases are often associated with muscle atrophy and heightened
inflammation. The whey bioactive compound, glycomacropeptide (GMP), has been shown to …

Obesity is often accompanied by heightened circulating and tissue inflammation along with
an increase in sphingolipids (eg, ceramides) in metabolically active and insulin-sensitive …

Skeletal muscle disorders are mostly genetic and include several rare diseases. With
disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The …

Poor recovery of muscle size and strength with aging coincides with a dysregulated
macrophage response during the early stages of regrowth. Immunomodulation in the form of …