TM-Free and TM-Catalyzed Mechanosynthesis of Functional Polymers

WKA Al-Ithawi, AF Khasanov, IS Kovalev, IL Nikonov… - Polymers, 2023 - mdpi.com
Highlights The most representative examples for the TM-free and TM-catalyzed mechano-
synthesis of functional polymers are reported; The most common applications for the various …

Multistep mechanochemical synthesis of PZ-1190, a multitarget antipsychotic agent

V Canale, M Kamiński, W Trybała… - ACS Sustainable …, 2023 - ACS Publications
A solid-state approach was used to synthesize compound PZ-1190, a multitarget ligand for
serotonin and dopamine receptors with potential antipsychotic activity in rodents. Compared …

Mechanochemical and microwave multistep organic reactions

D Margetic - Current Green Chemistry, 2024 - ingentaconnect.com
The development of more sustainable chemical reactions and processes has been the focus
of recent research activities. Advances in the field of organic synthesis have led to the …

Mechanochemical Pd-Catalyzed Amino- and Oxycarbonylations using FeBr2(CO)4 as a CO Source

T Čarný, P Kisszékelyi, M Markovič, T Gracza… - Organic …, 2023 - ACS Publications
Herein, we describe the development of mechanochemical amino-and oxycarbonylation
employing FeBr2 (CO) 4 as a solid CO source. This Pd/XantPhos-catalyzed reaction affords …

Rhodium (II)-Catalyzed N–H Insertions of Carbenes under Mechanochemical Conditions

S Biswas, C Bolm - Organic Letters, 2024 - ACS Publications
Under mechanochemical conditions in a mixer mill, Rh2 (OAc) 4 catalyzes the reaction
between aryldiazoesters and anilines to give α-amino esters. The process proceeds under …

Sustainable Synthesis of Diamondoid Ethers by High-Temperature Ball Milling

J Alić, T Stolar, Z Štefanić, K Užarević… - ACS Sustainable …, 2023 - ACS Publications
Diamondoids have emerged as promising carbon-based nanomaterial building blocks
because of their unique combination of exceptional properties and availability for selective …

Ball-Milling-Enabled Zn(OTf)2-Catalyzed Friedel–Crafts Hydroxyalkylation of Imidazo[1,2-a]pyridines and Indoles

N Meena, Bhawani, Sonam, K Rangan… - The Journal of Organic …, 2023 - ACS Publications
A facile and efficient synthetic method for the construction of C3-hydroxyalkylated imidazo [1,
2-a] pyridines and indoles by a Zn (OTf) 2-catalyzed Friedel–Crafts hydroxyalkylation of …

1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT6R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity

V Canale, W Trybała, S Chaumont-Dubel… - Biomolecules, 2022 - mdpi.com
In addition to the canonical Gs adenylyl cyclase pathway, the serotonin type 6 receptor (5-
HT6R) recruits additional signaling pathways that control cognitive function, brain …

Mechanosynthesis and Polymerization of Biosourced Styrene Derivatives Based on Building Blocks of Lignin

J Michalska-Walkowiak, E SN Antonio… - ACS Sustainable …, 2024 - ACS Publications
Finding and developing new biosourced materials that can compete with the current petro-
sourced ones are a top priority in order to transition to a more sustainable society. Although …

Prediction of Degradation Profiles for Various Sartans under Solvent-Free Mechanochemical Conditions

MM Amer, L Backer, H Buschmann, N Handler… - Analytical …, 2024 - ACS Publications
For the approval of a drug, the stability data must be submitted to regulatory authorities.
Such analyses are often time-consuming and cost-intensive. Forced degradation studies are …