Metabolic engineering is the science of rewiring the metabolism of cells to enhance
production of native metabolites or to endow cells with the ability to produce new products …

Metabolic engineering aims to develop efficient cell factories by rewiring cellular
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …

Saccharomyces cerevisiae is an efficient host for natural-compound production and
preferentially employed in academic studies and bioindustries. However, S. cerevisiae …

Malaria is a global health problem that threatens 300–500 million people and kills more than
one million people annually. Disease control is hampered by the occurrence of multi-drug …

The cytosol-localised mevalonic acid (MVA) pathway delivers the basic isoprene unit
isopentenyl diphosphate (IPP). In higher plants, this central metabolic intermediate is also …

Ergosterol (ERG) is a critical sterol in the cell membranes of fungi, and its biosynthesis is
tightly regulated by 25 known enzymes along the ERG production pathway. The effects of …

Abstract β-Carotene is a terpenoid molecule with high hydrophobicity that is often used as
an additive in foods and feed. Previous work has demonstrated the heterologous …

Microbial production can be advantageous over the extraction of phytoterpenoids from
natural plant sources, but it remains challenging to rationally and rapidly access efficient …

Isoprenoids are a class of natural products with more than 55,000 members. All isoprenoids
are constructed from two precursors, isopentenyl diphosphate and its isomer dimethylallyl …

Background Microbial production of lycopene, a commercially and medically important
compound, has received increasing concern in recent years. Saccharomyces cerevisiae is …