Introduction: Prior to 2006, nearly every US child was infected with rotavirus by 5 years of
age, and rotavirus was the leading cause of severe childhood gastroenteritis. In February …

The direct impact of vaccines on children is well described, but the major public health
impact of indirect protection provided to the community by vaccines is underappreciated …

Background The rotavirus disease burden has declined substantially since rotavirus vaccine
was introduced in the United States in 2006. The aim of this study was to determine the viral …

Noroviruses and other viral pathogens are increasingly recognized as frequent causes of
acute gastroenteritis (AGE). However, few laboratory-based data are available on the …

ABSTRACT Background Human milk oligosaccharides (HMOs) have antimicrobial and
immunomodulatory actions. It has previously been reported that these oligosaccharides …

Background Acute gastroenteritis (AGE) is a major cause of pediatric morbidity and mortality
around the world. It remains a frequent reason for infection-related admissions to emergency …

Among vaccines administered to children are those targeting rotavirus, a segmented double-
stranded RNA virus that represents a major cause of severe gastroenteritis. To explore the …

Reverse genetic systems have been used to introduce heterologous sequences into the
rotavirus segmented double-stranded (ds) RNA genome, enabling the generation of …

Background Rotavirus disease rates dramatically declined among children< 5 years of age
since the rotavirus vaccine was introduced in 2006; population-level impacts remain to be …

Background The direct effectiveness of infant rotavirus vaccination implemented in 2006 in
the United States has been evaluated extensively, however, understanding of population …