The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Lipid and immune pathways are crucial in the pathophysiology of metabolic and
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …

Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic
activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Chronic unresolved inflammation plays a causal role in the development of advanced
atherosclerosis, but the mechanisms that prevent resolution in atherosclerosis remain …

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding
hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid …

Non-resolving inflammation drives the development of clinically dangerous atherosclerotic
lesions by promoting sustained plaque inflammation, large necrotic cores, thin fibrous caps …

Cardiovascular disease, a leading cause of mortality worldwide, is caused mainly by
atherosclerosis, a chronic inflammatory disease of blood vessels. Lesions of atherosclerosis …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

The view of atherosclerosis as an inflammatory disease has emerged from observations of
immune activation and inflammatory signalling in human atherosclerotic lesions, from the …