Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

The avermectins and milbemycins contain a common macrocyclic lactone (ML) ring, but are
fermentation products of different organisms. The principal structural difference is that …

The broad-spectrum antiparasitic agent ivermectin has been very recently found to inhibit
SARS-CoV-2 in vitro and proposed as a candidate for drug repurposing in COVID-19. In the …

Ivermectin is a macrolide antiparasitic drug with a 16-membered ring that is widely used for
the treatment of many parasitic diseases such as river blindness, elephantiasis and scabies …

COVID-19 is announced as a global pandemic in 2020. Its mortality and morbidity rate are
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …

Anthelmintic resistance has a great impact on livestock production systems worldwide, is an
emerging concern in companion animal medicine, and represents a threat to our ongoing …

Parasitic helminths cause significant disease in animals and humans. In the absence of
alternative treatments, anthelmintics remain the principal agents for their control. Resistance …

Background: Multi-drug resistance (MDR) of cancer cells is an obstacle to effective
chemotherapy of cancer. The ATP-binding cassette (ABC) transporters, including P …

Background Discovery and development of novel drugs that are capable of overcoming drug
resistance in tumor cells are urgently needed clinically. In this study, we sought to explore …

Transporters in the human liver play a major role in the clearance of endo-and xenobiotics.
Apical (canalicular) transporters extrude compounds to the bile, while basolateral …