Cone snail venomics: from novel biology to novel therapeutics

JR Prashanth, A Brust, AH Jin, PF Alewood… - Future medicinal …, 2014 - Taylor & Francis
Peptide neurotoxins from cone snails called conotoxins are renowned for their therapeutic
potential to treat pain and several neurodegenerative diseases. Inefficient assay-guided …

Highlights of animal venom research on the geographical variations of toxin components, toxicities and envenomation therapy

C Yu, H Yu, P Li - International journal of biological macromolecules, 2020 - Elsevier
Geographical variation of animal venom is common among venomous animals. This kind of
intraspecific variation based on geographical location mainly concerned from envenomation …

The role of defensive ecological interactions in the evolution of conotoxins

JR Prashanth, S Dutertre, AH Jin, V Lavergne… - Molecular …, 2016 - Wiley Online Library
Venoms comprise of complex mixtures of peptides evolved for predation and defensive
purposes. Remarkably, some carnivorous cone snails can inject two distinct venoms in …

Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies

V Lavergne, S Dutertre, A Jin, RJ Lewis, RJ Taft… - BMC genomics, 2013 - Springer
Background Conopeptides, often generically referred to as conotoxins, are small
neurotoxins found in the venom of predatory marine cone snails. These molecules are …

Towards an integrated venomics approach for accelerated conopeptide discovery

JR Prashanth, RJ Lewis, S Dutertre - Toxicon, 2012 - Elsevier
Conopeptides and conotoxins are small peptides produced by cone snails as a part of their
predatory/defense strategies that target key ion channels and receptors in the nervous …

Wasp venomic: Unravelling the toxins arsenal of Polybia paulista venom and its potential pharmaceutical applications

A Perez-Riverol, JRA dos Santos-Pinto, AM Lasa… - Journal of …, 2017 - Elsevier
Abstract Polybia paulista (Hymenoptera: Vespidae) is a neotropical social wasp from
southeast Brazil. As most social Hymenoptera, venom from P. paulista comprises a complex …

Biochemical and electrophysiological characterization of two sea anemone type 1 potassium toxins from a geographically distant population of Bunodosoma …

DJB Orts, S Peigneur, B Madio, JS Cassoli… - Marine drugs, 2013 - mdpi.com
Sea anemone (Cnidaria, Anthozoa) venom is an important source of bioactive compounds
used as tools to study the pharmacology and structure-function of voltage-gated K+ …

Intraspecific variations in Conus purpurascens injected venom using LC/MALDI-TOF-MS and LC-ESI-TripleTOF-MS

AM Rodriguez, S Dutertre, RJ Lewis, F Marí - Analytical and bioanalytical …, 2015 - Springer
The venom of cone snails is composed of highly modified peptides (conopeptides) that
target a variety of ion channels and receptors. The venom of these marine gastropods …

Sexual dimorphism in venom gland morphology in a sexually stinging scorpion

L Sentenská, F Graber, M Richard… - Biological Journal of the …, 2017 - academic.oup.com
Males of several scorpion species possess bigger telsons than females. In at least some of
these species, males repeatedly sting females during mating. This behaviour ('sexual sting') …

Proteomics in behavioral ecology

CM Valcu, B Kempenaers - Behavioral Ecology, 2015 - academic.oup.com
Proteomics refers to the study of the protein complement expressed by a genome and aims
to understand protein expression, regulation, function, and interactions. Expression …