[HTML][HTML] Liquid-liquid phase separation as a common organizing principle of intracellular space and biomembranes providing dynamic adaptive responses
SV Nesterov, NS Ilyinsky, VN Uversky - Biochimica et Biophysica Acta (BBA …, 2021 - Elsevier
This work is devoted to the phenomenon of liquid-liquid phase separation (LLPS), which has
come to be recognized as fundamental organizing principle of living cells. We distinguish …
come to be recognized as fundamental organizing principle of living cells. We distinguish …
A classical revival: Human satellite DNAs enter the genomics era
N Altemose - Seminars in cell & developmental biology, 2022 - Elsevier
The classical human satellite DNAs, also referred to as human satellites 1, 2 and 3 (HSat1,
HSat2, HSat3, or collectively HSat1–3), occur on most human chromosomes as large …
HSat2, HSat3, or collectively HSat1–3), occur on most human chromosomes as large …
Long noncoding RNA URB1-antisense RNA 1 (AS1) suppresses sorafenib-induced ferroptosis in hepatocellular carcinoma by driving ferritin phase separation
Sorafenib, a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC),
has been shown to be a potent ferroptosis inducer in HCC. However, we found that there …
has been shown to be a potent ferroptosis inducer in HCC. However, we found that there …
Lnc RNA‐dependent nuclear stress bodies promote intron retention through SR protein phosphorylation
A number of long noncoding RNA s (lnc RNA s) are induced in response to specific stresses
to construct membrane‐less nuclear bodies; however, their function remains poorly …
to construct membrane‐less nuclear bodies; however, their function remains poorly …
m6A modification of HSATIII lncRNAs regulates temperature‐dependent splicing
Nuclear stress bodies (nSBs) are nuclear membraneless organelles formed around stress‐
inducible HSATIII architectural long noncoding RNAs (lncRNAs). nSBs repress splicing of …
inducible HSATIII architectural long noncoding RNAs (lncRNAs). nSBs repress splicing of …
LncRNAs: architectural scaffolds or more potential roles in phase separation
J Luo, L Qu, F Gao, J Lin, J Liu, A Lin - Frontiers in Genetics, 2021 - frontiersin.org
Biomolecules specifically aggregate in the cytoplasm and nucleus, driving liquid-liquid
phase separation (LLPS) formation and diverse biological processes. Extensive studies …
phase separation (LLPS) formation and diverse biological processes. Extensive studies …
Satellite RNAs: emerging players in subnuclear architecture and gene regulation
K Ninomiya, T Yamazaki, T Hirose - The EMBO journal, 2023 - embopress.org
Satellite DNA is characterized by long, tandemly repeated sequences mainly found in
centromeres and pericentromeric chromosomal regions. The recent advent of telomere‐to …
centromeres and pericentromeric chromosomal regions. The recent advent of telomere‐to …
LncRNAs divide and rule: The master regulators of phase separation
K Somasundaram, B Gupta, N Jain, S Jana - Frontiers in genetics, 2022 - frontiersin.org
Most of the human genome, except for a small region that transcribes protein-coding RNAs,
was considered junk. With the advent of RNA sequencing technology, we know that much of …
was considered junk. With the advent of RNA sequencing technology, we know that much of …
Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model
T Shibata, K Nagano, M Ueyama, K Ninomiya… - Nature …, 2021 - nature.com
Synthetic small molecules modulating RNA structure and function have therapeutic potential
for RNA diseases. Here we report our discovery that naphthyridine carbamate dimer (NCD) …
for RNA diseases. Here we report our discovery that naphthyridine carbamate dimer (NCD) …
Architectural RNAs for membraneless nuclear body formation
T Yamazaki, S Nakagawa… - Cold Spring Harbor …, 2019 - symposium.cshlp.org
Long noncoding RNAs (lncRNAs) are fundamental regulators of various cellular processes.
A subset of lncRNAs, termed architectural RNAs (arcRNAs), function in the formation and …
A subset of lncRNAs, termed architectural RNAs (arcRNAs), function in the formation and …