Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide
range of pediatric and adult malignances. However, it has various side effects which limit its …

Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy,
clinical benefit with OXPHOS inhibitors has yet to be achieved. Here we advanced IACS …

Next-generation transcriptomics in combination with imaging-based approaches have
emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal …

Background Despite the increasing knowledge of the etiology of neuropathic pain, this type
of chronic pain is resistant to available analgesics in approximately 50% of patients and …

Chemotherapy-induced peripheral neuropathy (CIPN) is a somatosensory axonopathy in
cancer patients receiving any of a variety of widely-use antitumor agents. CIPN can lead to …

ABSTRACT Introduction: Histone deacetylase 6 (HDAC6) is unique in comparison with other
zinc-dependent HDAC family members. An increasing amount of evidence from clinical and …

Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often
develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There is …

Chronic pain is a debilitating condition that influences the social, economic, and
psychological aspects of patients' lives. Hence, the need for better treatment is drawing …

Peripheral neuropathy, which is the result of nerve damage from lesions or disease,
continues to be a major health concern due to the common manifestation of neuropathic …