[HTML][HTML] Lipid droplet and its implication in cancer progression

Z Li, H Liu, X Luo - American journal of cancer research, 2020 - ncbi.nlm.nih.gov
Lipid droplets (LDs) are a kind of organelle that is commonly found in eukaryotic cells to
store lipids, which encompass a hydrophobic core composed of a single layer of …

Dropping in on lipid droplets: insights into cellular stress and cancer

P Shyu Jr, XFA Wong, K Crasta, G Thibault - Bioscience reports, 2018 - portlandpress.com
Lipid droplets (LD) have increasingly become a major topic of research in recent years
following its establishment as a highly dynamic organelle. Contrary to the initial view of LDs …

[HTML][HTML] Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer

A Royo-García, S Courtois, B Parejo-Alonso… - World journal of stem …, 2021 - ncbi.nlm.nih.gov
Previously regarded as simple fat storage particles, new evidence suggests that lipid
droplets (LDs) are dynamic and functional organelles involved in key cellular processes …

Clinical significance of carnitine in the treatment of cancer: from traffic to the regulation

R Farahzadi, MS Hejazi, O Molavi… - Oxidative Medicine …, 2023 - Wiley Online Library
Metabolic reprogramming is a common hallmark of cancer cells. Cancer cells exhibit
metabolic flexibility to maintain high proliferation and survival rates. In other words …

Bimodal effects on lipid droplets induced in cancer and non-cancer cells by chemotherapy drugs as revealed with a green-emitting BODIPY fluorescent probe

A Polita, R Žvirblis, J Dodonova-Vaitkūnienė… - Journal of Materials …, 2024 - pubs.rsc.org
Lipid droplets (LDs) are cytoplasmic lipid-rich organelles with important roles in lipid storage
and metabolism, cell signaling and membrane biosynthesis. Additionally, multiple diseases …

Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma

L Sainero-Alcolado, E Garde-Lapido… - Proceedings of the …, 2024 - National Acad Sciences
Metabolic reprogramming is critical during clear cell renal cell carcinoma (ccRCC)
tumorigenesis, manifested by accumulation of lipid droplets (LDs), organelles that have …

[HTML][HTML] Melatonin increases 5-flurouracil-mediated apoptosis of colorectal cancer cells through enhancing oxidative stress and downregulating survivin and XIAP

A Mihanfar, B Yousefi, SG Darband… - BioImpacts …, 2021 - ncbi.nlm.nih.gov
Methods: The effects of melatonin and 5-FU, alone or in combination, on cell proliferation
were evaluated using an MTT assay. Further, Annexin-V Flow cytometry was used for …

The role of circadian genes in the pathogenesis of colorectal cancer

SR Soofiyani, H Ahangari, A Soleimanian, G Babaei… - Gene, 2021 - Elsevier
Colorectal cancer (CRC) is the third most frequent cancer in human beings and is also the
major cause of death among the other gastrointestinal cancers. The exact mechanisms of …

Multiplex coherent anti-Stokes Raman scattering microspectroscopy detection of lipid droplets in cancer cells expressing TrkB

T Guerenne-Del Ben, V Couderc, L Duponchel, V Sol… - Scientific reports, 2020 - nature.com
For many years, scientists have been looking for specific biomarkers associated with cancer
cells for diagnosis purposes. These biomarkers mainly consist of proteins located at the cell …

Development of resistance to 5-fluorouracil affects membrane viscosity and lipid composition of cancer cells

L Shimolina, A Gulin, A Khlynova… - … and Applications in …, 2022 - iopscience.iop.org
The investigations reported here were designed to determine whether the bulk plasma
membrane is involved in mechanisms of acquired resistance of colorectal cancer cells to 5 …