Programmed cell death has a vital role in embryonic development and tissue homeostasis.
Necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis …

Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key
regulator of cell survival and aberrant NF-κB signaling has been involved in the …

Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members function in a cell context-specific and cell type-specific manner to integrate signals …

Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H 2 O
2) are thought to be byproducts of aerobic respiration with damaging effects on DNA …

The NF-κB family of transcription factors has an essential role in inflammation and innate
immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of …

The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …

Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number
of genes that are involved in important physiological processes, including survival …

The causes of sporadic human cancer are seldom recognized, but it is estimated that
carcinogen exposure and chronic inflammation are two important underlying conditions for …

The transcription factor NF-κB plays a major role in coordinating innate and adaptative
immunity, cellular proliferation, apoptosis and development. Since the discovery in 1991 that …