Abstract β-Lapachone (β-lap, 1), an ortho-naphthoquinone natural product isolated from the
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …

Naphthoquinones are of key importance in organic synthesis and medicinal chemistry. In the
last few years, various synthetic routes have been developed to prepare bioactive …

Naphthoquinoidal compounds are of great interest in medicinal chemistry. In recent years,
several synthetic routes have been developed to obtain bioactive molecules derived from …

The aims of this study were the planning, synthesis and in vitro evaluation of 2-hydroxy-3-
phenylsulfanylmethyl-[1, 4]-naphthoquinones against Gram-negative and Gram-positive …

We report the synthesis of 47 new quinone-based derivatives via click chemistry and their
subsequent evaluation against cancer cell lines and the control L929 murine fibroblast cell …

The capacity of different naphthoquinones to inhibit and eradicate Yersinia enterocolitica
biofilm was investigated and possible mechanisms of action were evaluated. Inhibition of …

Fluorescent quinone-based BODIPY hybrids were synthesised and characterised by NMR
analysis and mass spectrometry. We measured their cytotoxic activity against cancer and …

We report herein a straightforward and efficient one-step reaction to prepare new nor-β-
lapachone derivatives tethered with phenylthio groups at position 3 of the furan ring. We …

Helicteres genus, Malvaceae, has pantropical distribution, encompasses about 60 species,
31 of them found in Brazil. Species belonging to this genus are used for treatment of various …

A total of 28 lapachol‐related naphthoquinones with four different scaffolds were
synthesized and spectroscopically characterized. In vitro antiplasmodial activity was …