Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

The concept and development of bone/cartilage organoids are rapidly gaining momentum,
providing opportunities for both fundamental and translational research in bone biology …

Despite enormous advances, cardiovascular disorders are still a major threat to global
health and are responsible for one-third of deaths worldwide. Research for new therapeutics …

Abstract Treatment of large bone defects represents a great challenge in orthopedic and
craniomaxillofacial surgery. Traditional strategies in bone tissue engineering have focused …

Digital light processing (DLP) bioprinting is an emerging technology for three-dimensional
bioprinting (3DBP) owing to its high printing fidelity, fast fabrication speed, and higher …

Bone is one of the key components of the musculoskeletal system. Bone and joint disease
are the fourth most widespread disease, in addition to cardiovascular disease, cancer, and …

The human bone marrow (BM) niche sustains hematopoiesis throughout life. We present a
method for generating complex BM-like organoids (BMOs) from human induced pluripotent …

The bone marrow supports and regulates hematopoiesis, responding to physiological
requirements for blood cell production over ontogeny and during pathological challenges …

Early B cell development in the bone marrow ensures the replenishment of the peripheral B
cell pool. Immature B cells continuously develop from hematopoietic stem cells, in a process …

Recent years have seen the creation and popularization of various complex in vitro models
(CIVMs), such as organoids and organs-on-chip, as a technology with the potential to …