Muscle and neuronal nicotinic acetylcholine receptors: structure, function and pathogenicity

D Kalamida, K Poulas, V Avramopoulou… - The FEBS …, 2007 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …

Three-finger α-neurotoxins and the nicotinic acetylcholine receptor, forty years on

S Nirthanan, MCE Gwee - Journal of pharmacological sciences, 2004 - jstage.jst.go.jp
The discovery, about forty years ago, of a-bungarotoxin, a three-finger a-neurotoxin from
Bungarus multicinctus venom, enabled the isolation of the nicotinic acetylcholine receptor …

Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications

MR Picciotto, BJ Caldarone, DH Brunzell… - Pharmacology & …, 2001 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) in the muscle, autonomic ganglia, and brain are
targets for pharmacologically administered nicotine. Several of the subunits that combine to …

Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: Molecules, mechanisms and medicine

S Nirthanan - Biochemical pharmacology, 2020 - Elsevier
Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine …

PHN Celie, RV Klaassen… - Journal of Biological …, 2005 - ASBMB
The crystal structure of acetylcholine-binding protein (AChBP) from the mollusk Lymnaea
stagnalis is the established model for the ligand binding domains of the ligand-gated ion …

Nicotinic acetylcholine receptor inhibitors derived from snake and snail venoms

S Dutertre, A Nicke, VI Tsetlin - Neuropharmacology, 2017 - Elsevier
The nicotinic acetylcholine receptor (nAChR) represents the prototype of ligand-gated ion
channels. It is vital for neuromuscular transmission and an important regulator of …

[HTML][HTML] Snake and snail toxins acting on nicotinic acetylcholine receptors: fundamental aspects and medical applications

VI Tsetlin, F Hucho - FEBS letters, 2004 - Elsevier
This review covers recent data on interactions of nicotinic acetylcholine receptors (AChR)
with snake venom proteins (α-and κ-neurotoxins,'weak'toxins recently shown to act on …

Central role of α7 nicotinic receptor in differentiation of the stratified squamous epithelium

J Arredondo, VT Nguyen, AI Chernyavsky… - The Journal of cell …, 2002 - rupress.org
Several ganglionic nicotinic acetylcholine receptor (nAChR) types are abundantly
expressed in nonneuronal locations, but their functions remain unknown. We found that …

Inhibition of cell surface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell

SP Lee, BF O'Dowd, GYK Ng, G Varghese, H Akil… - Molecular …, 2000 - ASPET
Numerous mutant G protein-coupled receptors with diminished or no function have been
described that are naturally occurring or that are the product of gene manipulation. It has …

α7-nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogen-activated protein kinase pathway

S Trombino, A Cesario, S Margaritora, PL Granone… - Cancer Research, 2004 - AACR
This study presents data suggesting that both human mesothelioma (cell lines and human
mesothelioma biopsies) and human normal mesothelial cells express receptors for …