In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …

Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated
remarkable achievements. However, emerging evidence has shown that chemoresistance is …

In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has
achieved considerable success in the clinic. However, ICIs are significantly limited by the …

Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes, leading
to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and …

Programmed cell death (PCD) refers to the way in which cells die depending on specific
genes encoding signals or activities. Apoptosis, autophagy, and pyroptosis are all …

Background Bladder cancer (BLCA) is a common malignant tumor of the urinary tract, which
is the sixth most common cancer among men. Numerous studies suggested that pyroptosis …

Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied
in diverse inflammatory disease models. Membrane perforation and cell swelling induced by …

Gasdermin D (GSDMD) serves as a key executor to trigger pyroptosis and is emerging as an
attractive checkpoint in host defense, inflammatory, autoimmune diseases, and many other …