Since the serendipitous discovery of its anticonvulsant properties more than 50 years ago,
valproic acid has become established as an effective broad-spectrum antiepileptic drug that …

It is thought that germ cells and preimplantation embryos during development are most
susceptible to endogenous and exogenous environmental factors because the epigenome …

Background Fetal development is a crucial window of susceptibility in which exposure-
related alterations can be induced on the molecular level, leading to potential changes in …

Homocysteine is a metabolite generated by methionine cycle metabolism, comprising the
demethylated derivative of methionine. Homocysteine can be metabolised by the …

Schizophrenia (SCZ) is a complex, heritable and polygenic neuropsychiatric disease, which
disables the patients as well as decreases their life expectancy and quality of life. Common …

Background The incidence of neural tube defects (NTDs) declined by about 40% in Canada
with the introduction of a national folic acid (FA) fortification program. Despite the fact that …

Background Epigenetic mechanisms, such as altered DNA methylation, may participate in
the relationship between prenatal phthalate exposure and adverse birth outcomes …

Effective and powerful survival mediation models are currently lacking. To partly fill such
knowledge gap, we particularly focus on the mediation analysis that includes multiple DNA …

Abstract Background Neural tube defects (NTDs) are complex abnormalities associated with
gene-environment interactions. The underlying cause has not been determined. Methods …

Impairment of one-carbon metabolism during pregnancy, either due to nutritional
deficiencies in B9 or B12 vitamins or caused by specific genetic defects, is often associated …