Molecular basis of human sperm capacitation

LC Puga Molina, GM Luque, PA Balestrini… - Frontiers in cell and …, 2018 - frontiersin.org
In the early 1950s, Austin and Chang independently described the changes that are
required for the sperm to fertilize oocytes in vivo. These changes were originally grouped …

Artificial intelligence in reproductive medicine

R Wang, W Pan, L Jin, Y Li, Y Geng, C Gao… - …, 2019 - rep.bioscientifica.com
Artificial intelligence (AI) has experienced rapid growth over the past few years, moving from
the experimental to the implementation phase in various fields, including medicine …

Zika virus infection damages the testes in mice

J Govero, P Esakky, SM Scheaffer, E Fernandez… - Nature, 2016 - nature.com
Infection of pregnant women with Zika virus (ZIKV) can cause congenital malformations
including microcephaly, which has focused global attention on this emerging pathogen. In …

Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA

D Mashiko, Y Fujihara, Y Satouh, H Miyata, A Isotani… - Scientific reports, 2013 - nature.com
CRISPR/Cas mediated genome editing has been successfully demonstrated in mammalian
cells and further applications for generating mutant mice were reported by injecting …

Artificial intelligence in andrology: from semen analysis to image diagnostics

R Abou Ghayda, R Cannarella… - The World Journal …, 2023 - pmc.ncbi.nlm.nih.gov
Artificial intelligence (AI) in medicine has gained a lot of momentum in the last decades and
has been applied to various fields of medicine. Advances in computer science, medical …

[HTML][HTML] Mechanism of sperm capacitation and the acrosome reaction: role of protein kinases

D Ickowicz, M Finkelstein, H Breitbart - Asian journal of andrology, 2012 - ncbi.nlm.nih.gov
Mammalian sperm must undergo a series of biochemical and physiological modifications,
collectively called capacitation, in the female reproductive tract prior to the acrosome …

Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm− oocyte fusion in mice

T Noda, Y Lu, Y Fujihara, S Oura… - Proceedings of the …, 2020 - National Acad Sciences
Sperm− oocyte membrane fusion is one of the most important events for fertilization. So far,
IZUMO1 and Fertilization Influencing Membrane Protein (FIMP) on the sperm membrane …

Machine learning for sperm selection

JB You, C McCallum, Y Wang, J Riordon… - Nature Reviews …, 2021 - nature.com
Infertility rates and the number of couples seeking fertility care have increased worldwide
over the past few decades. Over 2.5 million cycles of assisted reproductive technologies are …

The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility

PH Wu, Y Fu, K Cecchini, DM Özata, A Arif, T Yu… - Nature …, 2020 - nature.com
Abstract Pachytene PIWI-interacting RNAs (piRNAs), which comprise> 80% of small RNAs
in the adult mouse testis, have been proposed to bind and regulate target RNAs like …

The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization

Y Fujihara, S Herberg, A Blaha… - Proceedings of the …, 2021 - National Acad Sciences
Fertilization is the fundamental process that initiates the development of a new individual in
all sexually reproducing species. Despite its importance, our understanding of the molecular …