SMC complexes: from DNA to chromosomes
F Uhlmann - Nature reviews Molecular cell biology, 2016 - nature.com
SMC (structural maintenance of chromosomes) complexes—which include condensin,
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …
The Smc5/6 complex: new and old functions of the enigmatic long-distance relative
L Aragón - Annual review of genetics, 2018 - annualreviews.org
Smc5 and Smc6, together with the kleisin Nse4, form the heart of the enigmatic and poorly
understood Smc5/6 complex, which is frequently viewed as a cousin of cohesin and …
understood Smc5/6 complex, which is frequently viewed as a cousin of cohesin and …
DNA entry into and exit out of the cohesin ring by an interlocking gate mechanism
Y Murayama, F Uhlmann - Cell, 2015 - cell.com
Structural maintenance of chromosome (SMC) complexes are proteinaceous rings that
embrace DNA to enable vital chromosomal functions. The ring is formed by two SMC …
embrace DNA to enable vital chromosomal functions. The ring is formed by two SMC …
The maintenance of chromosome structure: positioning and functioning of SMC complexes
K Jeppsson, T Kanno, K Shirahige… - Nature reviews Molecular …, 2014 - nature.com
Structural maintenance of chromosomes (SMC) complexes, which in eukaryotic cells include
cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome …
cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome …
Smc5/6 silences episomal transcription by a three-step function
F Abdul, A Diman, B Baechler… - Nature structural & …, 2022 - nature.com
In addition to its role in chromosome maintenance, the six-membered Smc5/6 complex
functions as a restriction factor that binds to and transcriptionally silences viral and other …
functions as a restriction factor that binds to and transcriptionally silences viral and other …
Cruciform structures are a common DNA feature important for regulating biological processes
V Brázda, RC Laister, EB Jagelská… - BMC molecular biology, 2011 - Springer
DNA cruciforms play an important role in the regulation of natural processes involving DNA.
These structures are formed by inverted repeats, and their stability is enhanced by DNA …
These structures are formed by inverted repeats, and their stability is enhanced by DNA …
Purified Smc5/6 complex exhibits DNA substrate recognition and compaction
P Gutierrez-Escribano, S Hormeño… - Molecular Cell, 2020 - cell.com
Eukaryotic SMC complexes, cohesin, condensin, and Smc5/6, use ATP hydrolysis to power
a plethora of functions requiring organization and restructuring of eukaryotic chromosomes …
a plethora of functions requiring organization and restructuring of eukaryotic chromosomes …
DNA segment capture by Smc5/6 holocomplexes
M Taschner, S Gruber - Nature Structural & Molecular Biology, 2023 - nature.com
Three distinct structural maintenance of chromosomes (SMC) complexes facilitate
chromosome folding and segregation in eukaryotes, presumably by DNA loop extrusion …
chromosome folding and segregation in eukaryotes, presumably by DNA loop extrusion …
Emerging roles of the MAGE protein family in stress response pathways
The melanoma antigen (MAGE) proteins all contain a MAGE homology domain. MAGE
genes are conserved in all eukaryotes and have expanded from a single gene in lower …
genes are conserved in all eukaryotes and have expanded from a single gene in lower …
Integrative analysis reveals unique structural and functional features of the Smc5/6 complex
Structural maintenance of chromosomes (SMC) complexes are critical chromatin
modulators. In eukaryotes, the cohesin and condensin SMC complexes organize chromatin …
modulators. In eukaryotes, the cohesin and condensin SMC complexes organize chromatin …