Calcium channel blockers: molecular docking and inhibition studies on carbonic anhydrase I and II isoenzymes

C Türkeş, Y Demir, Ş Beydemir - Journal of Biomolecular Structure …, 2021 - Taylor & Francis
Carbonic anhydrases (CAs) are potent dehydration of carbonic acid and catalyst of the
reversible hydration of carbon dioxide. Here, CA I and CA II was purified from human …

An approach to clarify the effect mechanism of glyphosate on body malformations during embryonic development of zebrafish (Daino rerio)

E Sulukan, M Köktürk, H Ceylan, Ş Beydemir, M Işik… - Chemosphere, 2017 - Elsevier
In this study, it has been investigated that the effects of glyphosate, which is a herbicide
within organophosphate and unselective widely used in agriculture on enzyme activity of …

Carbonic anhydrase inhibition by antiviral drugs in vitro and in silico

C Türkeş - Journal of Molecular Recognition, 2023 - Wiley Online Library
Enzyme inhibition is a commonly utilized method for controlling enzymatic activity in various
physiologically relevant biological systems. Herein, the selected five active antiviral drugs …

Bioactivity, cytotoxicity, and molecular modeling studies of novel sulfonamides as dual inhibitors of carbonic anhydrases and acetylcholinesterase

Ö Güleç, C Türkeş, M Arslan, Y Demir, B Dincer… - Journal of Molecular …, 2024 - Elsevier
In the present medical epoch, the prevailing approach of drug discovery, which focuses on
inhibiting a single target, has been superseded by the concept of designing drugs that target …

[HTML][HTML] Linarin prevents LPS‑induced acute lung injury by suppressing oxidative stress and inflammation via inhibition of TXNIP/NLRP3 and NF‑κB pathways

X Han, YC Wu, M Meng, QS Sun… - International …, 2018 - spandidos-publications.com
Acute lung injury (ALI) is an important cause of morbidity and mortality for critically ill
patients, and linarin (LR) may be a potential treatment for ALI as it reportedly has …

Evaluation of chalcones as inhibitors of glutathione S‐transferase

MS Özaslan, Y Demir, HE Aslan… - … of biochemical and …, 2018 - Wiley Online Library
Glutathione S‐transferases (GSTs) are the superfamily of multifunctional detoxification
isoenzymes and play an important role in cellular signaling. In the present study, potential …

Dynamics of small molecule-enzyme interactions: Novel benzenesulfonamides as multi-target agents endowed with inhibitory effects against some metabolic …

Ö Güleç, C Türkeş, M Arslan, M Işık, Y Demir… - Archives of Biochemistry …, 2024 - Elsevier
In contemporary medicinal chemistry, employing a singular small molecule to concurrently
multi-target disparate molecular entities is emerging as a potent strategy in the ongoing …

The effects of some cephalosporins on acetylcholinesterase and glutathione S-transferase: an in vivo and in vitro study

F Türkan, Z Huyut, Y Demir, F Ertaş… - Archives of physiology …, 2019 - Taylor & Francis
Abstract Background: Glutathione S-transferase (GST) and acetylcholinesterase (AChE) are
important enzymes in the metabolism. GSTs are primarily available in phase II metabolism …

Antiepileptic drugs: impacts on human serum paraoxonase‐1

Ş Beydemir, Y Demir - Journal of biochemical and molecular …, 2017 - Wiley Online Library
Serum paraoxonase (PON1) is a key enzyme related to high‐density lipoprotein (HDL)‐
cholesterol particle. It can prevent the oxidation of low‐density lipoprotein (LDL) and HDL …

Investigation of the effects of some sulfonamides on acetylcholinesterase and carbonic anhydrase enzymes

Z Köksal, Z Alım, S Bayrak, İ Gülçin… - Journal of Biochemical …, 2019 - Wiley Online Library
Human carbonic anhydrase I and II isoenzymes (hCA I and II) and acetylcholinesterase
(AChE) are important metabolic enzymes that are closely associated with various …