The low-voltage activated T-type calcium channels regulate cellular excitability and
oscillatory behavior of resting membrane potential which trigger many physiological events …

Voltage-gated calcium channels (VGCCs) represent a key link between electrical signals
and non-electrical processes, such as contraction, secretion and transcription. Evolved to …

T‐type channels are unique among the voltage‐gated calcium channels in their fast kinetics
and low voltages of activation and inactivation, the latter two features allowing them to …

Key points Mutations in the Cav3. 2 T‐type Ca2+ channel were found in patients with
idiopathic generalized epilepsies, yet the mechanisms by which these mutations increase …

Activity of voltage-gated Ca v 1.3 L-type Ca 2+ channels is required for proper hearing as
well as sinoatrial node and brain function. This critically depends on their negative activation …

Since cloning of the T-type or CaV3. n calcium channel family in 1998–1999 much progress
was made in investigation of their regulation. Most effectivemetalCaV3 channel blockers are …

The physiological functions controlled by T-type channels are intrinsically dependent on
their gating properties, and alteration of T-type channel activity is linked to several human …

Background and Purpose CaV3. 1‐3 currents differentially contribute to neuronal firing
patterns. CaV3 are regulated by G protein‐coupled receptors (GPCRs) activity, but …

We review the ins and outs of T-channel structure, focusing on the extracellular high-affinity
metal-binding site and intracellular loops. The high-affinity metal-binding site was localized …

Low-voltage-activated Ca V 3 channels are distinguished among other voltage-activated
calcium channels by the most negative voltage activation threshold. The voltage …