The Compression of Morbidity hypothesis—positing that the age of onset of chronic illness
may be postponed more than the age at death and squeezing most of the morbidity in life …

For the past 4 decades, many studies seeking to develop a definition and identify critical
determinants of successful aging have been published. To date, there is still no consensus …

We analyze the relationship between age of survival, morbidity, and disability among
centenarians (age 100–104 years), semisupercentenarians (age 105–109 years), and …

Like most complex phenotypes, exceptional longevity is thought to reflect a combined
influence of environmental (eg, lifestyle choices, where we live) and genetic factors. To …

The purpose of this study was to examine the association of disability and co-morbidity with
frailty in older adults. 2305 participants aged 65+ from the second wave of the Canadian …

By studying the loci that contribute to human longevity, we aim to identify mechanisms that
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …

Objectives. To propose and test a conceptual two-factor model of successful aging that
includes objective and subjective components. Methods. Data were derived from 5,688 …

Leukocyte telomere length (LTL) and rate of telomere shortening are known biomarkers of
aging while, numerous studies showed that Mediterranean diet (MD) may boost longevity …

Obesity is a worldwide problem with increasing prevalence and incidence in both developed
and developing countries. In older adults, excess weight is associated with a higher …

Centenarians are remarkable not only because of their prolonged life, but also because they
compress morbidity until the very last moments of their lives, thus being proposed as a …